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題 名 | Liquid Ventilation for Treatment of Meconium Aspiration Syndrome in a Piglet Model=以小豬模式研究液體呼吸治療胎便吸入症候群 |
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作 者 | 郭啟昱; 薛純; 王超然; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 97:6 1998.06[民87.06] |
頁 次 | 頁392-399 |
分類號 | 417.53 |
關鍵詞 | 小豬模式; 液體呼吸; 胎便吸入症候群; Meconium aspiration syndrome; Liquid ventilation; Perfluorocarbon; |
語 文 | 英文(English) |
英文摘要 | We tested the hypothesis that liquid ventilation (LV) with perfluorocarbon (PFC) can remove aspirated meconium and improve lung function in experimental meconium aspiration syndrome (MAS). PFC (FC- 77) was used as the medium in LV. Sixteen piglets were divided into control and LV groups (8 animals/group). All animals received slurry meconium (20% in normal saline) via endotracheal instillation at baseline. Thirty minutes later, the LV group received 15 cycles of LV. Pulmonary mechanics, arterial blood gases, and hemodynamic values were recorded at baseline, and 30, 60, 120, 180, and 240 minutes after meconium instillation. Chest radiographs and lung sections were taken and scored at the end of the study. The percentage of meconium cleared by LV was calculated as the ratio of the dry weight of washings to that of meconium instilled, multiplied by 100. The procedure was tolerated well by the animals. LV cleared 25% ±7% of the instilled meconium. Tidal volume (9.5±2.0 vs 7.1±0.8 mL/kg, p=0.012), respiratory system compliance (2.32±0.60 vs 1.60± 0.24mL/cmH□O, p=0.01), PaO□ (65±7 torr vs 55±6 torr, p=0.0067), and arterial to alveolar oxygen ratio (0.14±0.01 vs 0.12±0.01, p=0.0077) were improved in the LV group at 60 minutes after meconium instillation compared with those of the control group. The scores of exudative debris (1.7±0.3 vs 2.1±0.2) and visible meconium (1.4±0.5 vs 2.1±0.5) were significantly lower in the LV group. In conclusion, short-term LV with FC-77 can partially remove aspirated meconium from the lungs and improve pulmonary function transiently. |
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