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題名 | Extent of Collateral Sprouting of Intact Nerve Fibers in Rats Depends on the Local Availability of Nerve Growth Factor=鼠神經纖維之側枝芽生依賴局部神經生長激素的證據 |
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作者 | 羅榮昇; 陳獻宗; 鄧樂明; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 97:4 1998.04[民87.04] |
頁次 | 頁247-251 |
分類號 | 415.9 |
關鍵詞 | 鼠; 神經纖維; 神經生長激素; Nerve growth factor; Anti-nerve growth factor serum; Chronic constriction injury; Collateral sprouting; Neuropathic pain; |
語文 | 英文(English) |
英文摘要 | We investigated the influence of local administration of anti-nerve growth factor (NGF) serum on collateral nerve fiber sprouting caused by chronic constriction injury (CCI) of the sciatic nerve in rats. CCI was induced in adult Sprague-Dawley rats (six per group) by constriction of the sciatic nerve of the right hind limb. Control rats received no further manipulation. In four other groups, rabbit preimmune (control) serum or low (18 ng) or high (1800 ng) doses of anti-NGF serum were injected into the operated or unoperated hind limb each day for 1 month. We used an Evans dye-labeled plasma extravasation technique to visualize the extent of collateral sprouting. Local injection of anti-NGF serum at both high and low doses, but not control serum, significantly reduced the spread of collateral sprouting from the saphenous nerve into the sciatic nerve innervation territory. High-dose anti-NGF serum did not block collateral sprouting when injected into the contralateral (unoperated) hind limb, indicating that the inhibition of sprouting was not caused by a systemic effect. In conclusion, local administration of anti-NGF serum can block sprouting of collateral fibers after nerve injury. Our findings suggest that collateral sprouting is dependent on the local availability of NGF to nearby intact cutaneous nerve fibers. |
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