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題 名 | Role of p21□ and p27□ in Predicting Biochemical Recurrence for Organ-confined Prostate Adenocarcinoma=p21□和p27□表現預測局限性攝護腺癌預後之價值 |
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作 者 | 吳東霖; 王志生; 簡邦平; 余家政; 蔡政諭; 林仁泰; 黃榮慶; | 書刊名 | 中華醫學會雜誌 |
卷 期 | 70:1 2007.01[民96.01] |
頁 次 | 頁11-15+CA2 |
分類號 | 416.275 |
關鍵詞 | 預後; 攝護腺癌; p21; p27; Prognosis; Prostate neoplasms; |
語 文 | 英文(English) |
中文摘要 | 背景:□和□蛋白都曾被報告過和攝護腺癌的預後有關,本研究之目的在分析□和□蛋白與臺灣局限性攝護腺癌患者預後之關聯。 方法:我們回溯性分析了53位病理期別為第二期之攝護腺癌患者,將攝護腺標本染以抗□和□抗體。生化學上的復發之定義為連續兩次血清攝護腺特異抗原值大於0.2ng/mL;分別評估□和□蛋白表現對局限性懾護腺病患者預後之預測價值。 結果:19位患者(35.8%)呈現□染色陽性,29個標本(54.7%)出現□表現不足,兩者皆與腫瘤分化程度不相干(p值都是1.00)。在中位數為49個月的追蹤期中,15位患者(28.3%)發生化學上的復發,但不論□或□蛋白表現皆無法預測術後之復發(log-rank 檢查p值分別為0.98和0.64)。 結論:□和□蛋白表現對局限性攝護腺癌患者的預後均無預測價值。 |
英文摘要 | Background: Both p21WAF1 and p27KIP1 have been reported as prognostic markers predicting biochemical failure for prostate cancers. We examined the expression and prognostic significance of p21WAF1 and p27KIP1 in organ-confined (pT2) prostate cancer patients. Methods: The medical records of 53 pT2 prostate adenocarcinomas were analyzed retrospectively. Radical prostatectomy specimens were stained using anti-p21WAF1 and anti-p27KIP1 antibodies. Biochemical relapse was defined as 2 consecutive elevations in serum prostate specific antigen (PSA) level >0.2 ng/mL with an interval of more than 3 months. The prognostic significance of p21WAF1 and p27KIP1 expression was assessed. Results: p21WAF1 immunoreactivity was found in 19 patients (35.8%). Twenty-nine tumors (54.7%) had decreased p27KIP1 expression. Both markers were not associated with Gleason scores (p =1.00 for both). At a median follow-up of 49 months, 15 patients (28.3%) experienced biochemical recurrence. Both p21 and p27 had no prognostic significance in log-rank test (p =0.98 and p =0.64, respectively). Conclusion: p21WAF1 and p27KIP1 expression have no role in predicting biochemical relapse for stage pT2 prostate cancers. |
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