頁籤選單縮合
題名 | 中藥藥理之研究:十種止喘中藥之藥理評估=Pharmacological Studies of Chinese Herbal Drugs: Pharmacological Evalutaion of Ten Anti-Asthmatic Chinese Herbal Drugs |
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作者 | 廖志飛; | 書刊名 | 中醫藥年報 |
卷期 | 16:2 1998.05[民87.05] |
頁次 | 頁15-38 |
分類號 | 414.5 |
關鍵詞 | 氣管舒張作用; 中藥; 藥物接受器; 苦參; 山豆根; 款冬花; 香附; 艾葉; Bronchial relaxing effects; Chinese herbal drugs; Drug receptors; Sophorae radix; Menispermi rhizoma; Farfarae flos; Cyperi rhizoma; Artemisiae argyi folium; |
語文 | 中文(Chinese) |
中文摘要 | 為了探討具有止喘作用之中藥是否直接作用在呼吸道平滑肌, 本研究評估苦參、秦皮、山豆根、苦杏仁、紫菀、款冬花、枇杷 葉、香附。側柏葉、艾葉等十種中藥之水抽提物對carbachol、 histamine、KCL引致天竺鼠離體氣管收縮之舒張作用。如以產生 50%舒張所需之濃度(IC�t)為每毫升含30毫克原生藥重當具有顯 著作用之指標,則可舒張 carbachol(10���貽)收縮作用者有(IC�t, mg/ml):苦參(7.1)、山豆根(0.7)、紫菀(21.8)、款冬花 (12.0)、香附(12.7)、艾葉(14.3);可舒張histamine (10�笐�)收 縮作用者有:苦參(22.7)、山豆根(13.7)、香附(18.0)、艾葉 (16.5);可舒張KCl (60 mM)收縮作用者有:苦參(26.6)、秦皮 (28.0)、山豆根(15.0)、香附(8.3)、艾葉(18.7)。由IC�t值之 比較知對carbachol 作用較有選擇性者有:苦參、山豆根、紫菀; 對KC1作用較有選擇性者有:香附。山豆根對carbachol之濃度-- 舒張作用曲線可因b型交感神經接受器拮抗劑 propranolol(10���貽) 存在下向右移,顯示山豆根之作用有b型交感神經接受器活化之參 與。接受器結合實驗顯示除香附、側柏葉外,其餘八種中藥均可與 muscarinic acetylcholine (M)、histamine H��(H��)接受器或L 型鈣離子通道之dihydropyridine(DHP)結合處有相互作用。這些 結果對上述中藥舒張氣管之作用機轉提供是否直接作用在M、H�絞� 受器或DHP 結合處層面之證據。 |
英文摘要 | In order to evaluate whether anti-asthmatic Chinese herbal drugs directly act on the airway smooth muscles, the present study examined the relaxing effects of the water extracts from Sophorae radix (SR), Fraxini cortex (FC), Menispermi rhizoma (MR), Armeniacae semen (AS), Asteris radix et rhizoma (ARR), Farfarae flos (FF), Eriobotryae folium (EF), Cyperi rhizoma (CR), Biotae folium et ramulus (BFR), and Artemisiae argyi folium (AAF) on carbachol-, histamine-and KCl-induced contractions of the guinea-pig isolated tracheal preparations. When the IC�tvalue was set at or below 30 mg/ml as an index, the drugs showed significant effects were (IC�t, mg/ml): SR(7.1), MR(0.7), ARR (21.8), FF (12.0), CR (12.7), and AAF (14.3) for carbachol (10���貽); SR (22.7), MR (13.7), CR (18.0), and AAF (16.5) for histamine (10�笐弸); SR (26.6), FC (28.0), MR (15.0), CR (8.3), and AAF (18.7) for KCl (60 mM). When the IC�t values among three spasmogens for each drug were compared, the drugs showed selective action were SR, MR, and ARR for carbachol and CR for KCl. The concentration-relaxing effect curve of MR on carbachol-induced contractions was shifted to the right by the pretreatment of a b-adrenoceptor antagonist propranolol (10���貽), indicting the activation of b-adrenoceptors was involved in the relaxing effect of MR. Receptor binding assays indicated that 8 Chinese drugs, except CR and BFR, interacted with the muscarinic acetylcholine (M), histamine H�皴eceptors, or the dihydropyridine (DHP) binding site of L-type Ca�� channel. Therefore, these results provided the evidence to explain the action mechanisms of bronchial relaxing effects of these Chinese drugs at the level of M, H�皴eceptors or DHP binding sites. |
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