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題名 | ADP-Induced Platelet Aggregation in Hypothyroid and Normal Subjects=甲狀腺功能低下症之血小板凝聚力 |
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作者 | 李欣宇; 施婷婷; 李少白; 宣立人; 高美燈; 陳華芬; Lee, Hsin-yu; See, Ting-ting; Lee, Siu-pak; Shian, Lee-ren; Kao, Mei-teng; Chen, Hue-fen; |
期刊 | 醫學研究 |
出版日期 | 19980300 |
卷期 | 18:5 1998.03[民87.03] |
頁次 | 頁321-325 |
分類號 | 415.931 |
語文 | eng |
關鍵詞 | 甲狀腺功能低下症; 血小板凝聚力; 二燐酸腺甘酸; Hypothyroidism; Platelet aggregation; ADP; |
中文摘要 | 甲狀腺功能不足與冠狀動脈疾病及高血酯症有著密切的關係,高血症酯會增加血小板之凝聚力及促使血管硬化。本文探討甲狀腺功能、血酯肪及血小板凝聚力之關係。本報告比較十五名甲狀腺功能低下症患者與其對照組之血小板凝聚力、血酯肪濃度及血小板數目。甲狀腺低下症病患與其對照組之血酯肪濃度並無統計上之差別。可是甲狀腺功能低下症之患者之血小板凝聚力確比對照高。本報告發現血小板凝聚力與患者的膽固醇濃度並沒有直接之關係,甲狀腺素不足本身可能會增加血小板凝聚力,這可能是增加甲狀腺低下症者罹患冠狀動脈疾病的因素之一。 |
英文摘要 | Hypothyroidism was found to be associated with coronary artery disease and hypercholestero-lemia. Hyperlipidemia may cause an increase in platelet aggregability and formation of atheroma. The aim of our study is to investigate the relationship between thyroid function, serum lipid and patelet aggregability. Fifteen hypothyroid patients and fifteen age and sex matched control subjects were included in the study. Blood samples were collected and platelet aggregability, total serum cholesterol, triglyceride and platelet numbers were determined. There were no significant differences between hypothyroid and control group in total cholesterol and triglyceride levels. However, the percentage of platelet aggregation was significantly higher in hypothyroid than control group. Our study showed that platelet aggregability was higher in these patients which might not be related to serum cholesterol levels. Therefore, thyroid hormone deficiency per se might lead to increase in platelet aggregability. The increase in platelet aggregation might be one of the contributory factors to atherosclerotic heart disease in hypothyroid patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。