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題 名 | The Effect of Large-Dose Prednisolone on Patients with Obstructive Lung Disease Associated with Consuming Sauropus Androgynus=大劑量類固醇治療減肥蔬菜引起阻塞性肺疾病的效果 |
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作 者 | 吳杰亮; 徐武輝; 江自得; | 書刊名 | 中華醫學雜誌 |
卷 期 | 61:1 1998.01[民87.01] |
頁 次 | 頁34-38 |
分類號 | 415.46 |
關鍵詞 | 類固醇; 減肥蔬菜; 阻塞性肺疾病; Sauropus androgynus; Prednisolone treatment; Pulmonary function test; Obstructive lung disease; |
語 文 | 英文(English) |
中文摘要 | 背景:在1995年,臺灣地區爆發食用減肥蔬菜引起阻塞性肺病變。肺部病理檢查 顯示阻塞性細支氣管炎,有些合併器質性肺炎。儘管病理機轉仍不清楚,類固醇正被嘗試用以治療這些病患。 方法:我們回顧七位食用了減肥蔬菜引起阻塞性肺疾病的不抽煙女性。以傳統肺功能檢查評估大劑量類固醇治療(每天每公斤體重大於0.5毫克且療程長於30天)前後之效果。 結果:所有病人在治療前第一秒呼氣容債(FEV□)均明顯降低。比較治療前後第一秒呼氣容積(FEV□)、用力呼氣肺活量(FVC)、兩者比值、及一氧化碳肺瀰散量測定,均無統計學上有意義的差異。 結論:以大劑量類固醇治療不能改善減肥蔬菜引起的阻塞性肺疾病。 |
英文摘要 | Background: In 1995, the consumption of the vegetable Sauropus androgynus in order to reduce weight led to an outbreak of patients with obstructive ventilatory impairment. The pathologic findings showed bronchiolitis obliterans with or without organized pneumonia. Steroid therapy was used in an attempt to reverse the pulmonary dysfunction even though the pathogenesis was unknown. Methods: In this retrospective study, we reviewed the response of seven non-smoking female patients who were consuming Sauropus androgynus to large-dose prednisolone therapy (prednisolone > 0.5 mg/kg/day, > 30 days). Conventional pulmonary function testing (PFT) was used to assess patient lung function. Results: All patients had greatly reduced forced expiratory volume in one second (FEVI) before and after steroid treatment. There was no significant change in the parameters of PFT, such as FEVJ, forced vital capacity (FVC), FEV,/FVC, and carbon monoxide diffusion capacity (DLco) after prednisolone therapy. Conclusions: Large-dose steroid therapy was unable to relieve the obstructive ventilatory impairment present in patients after consuming Sauropus androgynus. |
本系統中英文摘要資訊取自各篇刊載內容。