頁籤選單縮合
題 名 | Drug Release from Directly-compressed Compacts Prepared with Different Particle Sizes of Ethylcellulose and with Other Excipients |
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作 者 | 林山陽; 林宮旭; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:1 1998.02[民87.02] |
頁 次 | 頁33-42 |
分類號 | 418.4 |
關鍵詞 | Ethylcellulose; Compact; Release mechanism; Particle size; Excipient; Combined ratio; |
語 文 | 英文(English) |
英文摘要 | Sodium diclofenac-loaded ethylcellulose (EC) compacts were directly compressed in an IR spectrophotometric press under a constant pressure of 300 kg/cm�� for one minute. The compacts were made with different particle sizes of EC powders, various combined ratios of small (4.6 μ m) and large (398 μ m) EC particles, or different combined ratios of EC powders (4.6 μ m) and directly compressible excipients (microcrystalline cellulose, lactose or HPMC). The dissolution behavior of these compacts was determined in distilled water and/or pH 6.8 phosphate buffer solution. The drug release mechanism was determined by the reduced time method and explained by the Higuchi diffusion model. Correlations between the release kinetics and the combined ratios were explored. The results indicate that the EC compacts made with small EC particles displayed slower release behavior compared to EC compacts prepared with the large particles. Release was slower in EC compacts containing a higher content of small particles than large ones, suggesting that the particle size played a predominant role in controlling drug release. Combination of directly compressible excipients into EC compacts also influenced the release behavior, depending on the type and physico-chemical properties of the excipient. These results imply that the EC particle size and type of excipient play an important role in controlling drug release from EC compacts. |
本系統中英文摘要資訊取自各篇刊載內容。