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題 名 | The Origins of Nucleic Acid and Peptide Stability:Quantitative Analyses of Physicochemical Properties and Molecular Orbital Calculation |
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作 者 | Lien,Eric J.; Ren,Shijun; | 書刊名 | 中華藥學雜誌 |
卷 期 | 50:1 1998.02[民87.02] |
頁 次 | 頁1-12 |
分類號 | 418.4 |
關鍵詞 | Nucleic acid bases; Physicochemical properties; Dipole moment; Heat of formation; Peptide; Dehydration; Hydrolysis; Thermodynamics; |
語 文 | 英文(English) |
英文摘要 | Quantitative analyses of the origins of nucleic acid and peptide stability have been performed based n physicochemical properties (dipole moment, hydrophobicity, molar refractivity and hydrogen bonds) and molecular orbital calculation. Both dipole moment and molar refractivity have been shown to be complementary between the base pairs and the antiparallel strands of nucleic acids. By calculations of the energy of the highest occupied molecular orbital and the energy of the lowest unoccupied molecular orbital of nucleic acid bases, it has been found that guanine is the strongest nucleophile, making the C-G base pair a preferential site among all base pairs for covalent bond formation by an electrophile (e.g. alkylating agent, aziridinium ion and carbonium ion). The stepwise calculations of the heats of formation have shown that all dehydration reactions involved in the syntheses of peptides, nucleic acids, and various high energy compounds are endothermic. The dehydration step provides the unique structural properties and a common biochemical energy storage mechanism. Solar energy provided the energy needed for the dehydration step during the primordial period in the formation of living organisms. It continues to do so through photosynthesis to provide the ultimate source of bioenergy for both plant and animal kingdoms. |
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