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頁籤選單縮合
題名 | Acetaminophen Overdose in Children and Adolescents=兒童及青少年之服食過量乙酼胺基酚(Acetaminophen) |
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作者 | 林思偕; 趙舜卿; 黃璟隆; 林奏延; 謝貴雄; Lin, Syh-jae; Chao, Hsun-chin; Huang, Jing-long; Lin, Tzou-yien; Hsieh, Kue-hsiung; |
期刊 | 中華民國小兒科醫學會雜誌 |
出版日期 | 19971100、19971200 |
卷期 | 38:6 民86.11-12 |
頁次 | 頁448-453+498 |
分類號 | 418.224 |
語文 | eng |
關鍵詞 | 乙酼胺基酚; 肝毒性; 兒童; Acetaminophen overdose; Hepatoxicity; Drug intoxication; |
英文摘要 | From 1982 to 1997, 12 Chinese children were admitted to Chang Gung Memorial Hospital with acetaminophen overdose. Six subjects (one young child, and five adolescents) developed liver damage which was severe in three cases (AST>1000 IU/L). Acetaminophen-induced liver function abnormalities were characterized by elevation of transaminase levels with ALT higher than AST(6/6), coagulopathy(5/6), thrombocytopenia (1/6), but absence of jaundice(6/6). Fortunately, none of the six patients with liver damage developed fulminant liver failure, and all recovered completely. Acetaminophen overdose can cause significant mnorbidity in children and adolescents. Caretakers should be well instructed to give the drug correctly. So far, acetaminophen is still considered as the drug-of-choice for antipyresis in pediatric practice. However, multicentered collaborative study is necessary to determine whether acetaminophen intoxication causes less hepatic failure in Chinese children than in Western children. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。