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題 名 | Clinical and Laboratory Correlation of Acute Henoch-Schonlein Purpura in Children=急性Henoch-Schonlein紫斑症病童之臨床檢驗之相關性 |
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作 者 | 林思偕; 黃璟隆; 謝貴雄; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 39:2 民87.03-04 |
頁 次 | 頁94-98+130 |
分類號 | 417.5516 |
關鍵詞 | Henoch-Schonlein紫斑症; 白血球; C-反應蛋白; 血小板; Henoch-Schonlein purpura; Leukocytosis; Thrombocytosis; C-reactive protein; |
語 文 | 英文(English) |
中文摘要 | 吾人回顧分析七年間七十二名急性Henoch-Schonlein紫斑症病童之臨床表現與實 驗室檢驗和白血球(WBC),血清C-反應蛋白(CRP)及血小板(PLT)之關聯性。病童之年紀由 兩歲至十五歲:有46位男孩及26位女孩。臨床表現方面:皮疹有72位(100%),腹痛有44 位(61.1%),關節炎有39位(54.2%),胃腸出血有25位(均有腹痛症狀)(34.7%),腎炎有14位 (19.2%)。WBC>15000/mm ,血清CRP>10mg/L及PLT>400x10 /mm 分別均與腸胃 出血症狀有相關性,而三者均與僅有腹痛卻無腸道出血之症狀無相關性。三者均與關節炎、 腎炎表現無顯著相關。血清C反應蛋白之昇高與延長住院日數有關,故可作為偵測疾病嚴 重性之指標。腸胃出血症狀之百分比在WBC,CRP,PLT三種檢查均正常之病人為0% (0/19), 僅有一項升高為21.7% (5/23),有兩項升高者50% (8/16),三項均昇高者85.7% (12/14)。具 腸胃出血症狀病人之平均WBC值,血清CRP值及血小板數均顯著高於僅有腹痛而無出血 之病人,與無腹痛之症狀之病人。故於急性Henoch-Schonlein紫斑症病童常規檢驗此三種指 標有其價值。 |
英文摘要 | The clinical and laboratory features of 72 children with Henoch-Schonlein purpura (HSP) were examined to determine if there were associations between the laboratory indices—including white blood cell (WBC) counts, serum C-reactive protein (CRP) levels, platelet (PLT) counts—and the clinical manifestations of acute HSP. Marked leukocytosis (WBC > 15000/mm ), elevation of serum CRP levels (> 10 mg/L) and thrombocytosis (PLT > 400x10 /mm ) were associated with gastrointestinal (GI) bleeding, but not associated with abdominal pain in the absence of GI bleeding. None of the three parameters was associated with arthritis and nephritis. Elevated serum CRP levels alone was accociated with prolonged hospital course, and may serve as an indicator of disease severity in patients with HSP. GI bleeding did not occur in patients with normal WBC counts, serum CRP levels, PLT counts (0/19), but occurred in 21.7% (5/23), 50% (8/16), and 85.7% (12/14) in patients with only one, two of the three and all three laboratory abnormalities, respectively. Patients with GI bleeding had higher mean WBC, PLT counts and serum CRP levels than those with abdominal pain in the absence of GI bleeding, and than those without abdominal pain. Routine measurement of these parameters is warranted to monitor children with acute HSP. |
本系統中英文摘要資訊取自各篇刊載內容。