頁籤選單縮合
題 名 | Pathophysiology of Growth Retardation in Chronic Renal Failure=慢性腎衰竭病童生長遲緩之病理生理學 |
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作 者 | Saborio,Pablo; Krieg,Richard J.; Chan,Winnie; Hahn,Seunghoon; Chan,James C. M.; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 39:1 民87.01-02 |
頁 次 | 頁21-27 |
分類號 | 417.593 |
關鍵詞 | Chronic renal failure; Growth failure; Growth hormone; Insulin-like growth factor; |
語 文 | 英文(English) |
英文摘要 | Data concerning the transcription of growth hormone and the various interactions between growth hormone/insulin-like growth factor ( IGF ) axis in uremia, acidosis and nutrition are presented. The recent evidence of tissue resistance to growth hormone in uremia provided the medical rationale for the use of growth hormone in chronic renal failure. The growth hormone receptor resistance in uremia and the decreased IGF-I by acidosis are additional rationale for the use of growth hormone. New findings of how acidosis causes the reduction of IGF-I expression at the growth plate of the long bone and the significant proteolysis after even small changes in serum bicarbonate content are presented to provide the pediatrician with an overview of these recent advances. |
本系統中英文摘要資訊取自各篇刊載內容。