查詢結果分析
來源資料
頁籤選單縮合
題 名 | 快速生長分枝桿菌之生體外藥物敏感試驗=In Vitro Antimicrobial Susceptbility Testing of Rapidly Growing Mycobacteria |
---|---|
作 者 | 余明治; 吳玫華; 翁宗輝; 索任; 林道平; | 書刊名 | 胸腔醫學 |
卷 期 | 12:4 1997.12[民86.12] |
頁 次 | 頁155-160 |
分類號 | 415.2773 |
關鍵詞 | 快速生長分枝桿菌; 藥物敏感試驗; Rapidly growing mycobacteria; Drug susceptibility test; |
語 文 | 中文(Chinese) |
中文摘要 | 在臺灣由病患痰中分離出快速生長分枝桿菌,似乎有日漸增多的趨勢。我們回溯性的統計於民國85年1月到86年8月間在臺灣省慢性病防治局完成鑑定的22株快速生長分枝桿菌的藥物敏感試驗結果。其中15株為 Mycobacterium abscessus,2株為 Mycobacterium Chelonae,5株為 Mycobacterium fortuitum。藥物敏感試驗分兩方面檢測: (一)以絕對濃度法(absolute concentration method)對傳統的抗結核藥物進行試驗; (二)以紙錠擴散法(disk diffusion method)進行一般抗生素的試驗。 結果顯示:所有快速生長分枝桿菌皆普遍對傳統抗結核藥物具有抗藥性。M.abscessus 及M.chelonae僅對 amikacin、kanamycin及clarithromycin 有效,其餘抗生素幾乎皆無效;但 M.fortuitum 除對 amikacin、kanamycin、cefmetazole、imipenem、ofloxacin 及ciprofloxacin 相當有效外,clarithromycin 及cefoxitin 亦常具效果。故我們認為:即使病人罹患快速生長分枝桿菌,只要審慎地依藥物敏感試驗結果,投予有效藥物,仍能使得病患恢復健康。 |
英文摘要 | Rapidly growing mycobacteria (RGM) are being increasing isolated from sputum of patients in Tawian. We retrospectively reviewed the results of drug susceptibility testing of RGM identified in Taiwan Provincial Chronic Disease Control Bureau from January 1996 to August 1997. There are twenty-two isolates, including 15 isolates of mycobacterium abscessus, 2 of Mycobacterium chelonae and 5 of Mycobacterium fortuitum. We use absolute concentration method for the susceptibility test of traditional antituberculosis drugs and disk diffusion method for the common antibiotics. RGM are generally resistant to traditional antituberculosis drugs. M. abscessus and M. chelonae are susceptible to amikacin, kanamycin and clarithromycin, while resistant to most of the other antibiotics. M. fortuitum are susceptible mainly to amikacin, kanamycin, cefmetazole, imipenem, ofloxacin, ciprofloxacin, cefoxitin and clarithromycin. We suggest that if we can treat the patients with RGM Using a regimen based on the result of drug susceptibility testing, many patients still can recover from their illness. |
本系統中英文摘要資訊取自各篇刊載內容。