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題名 | 泰妙素(Tiamulin)與孟寧素(Monensin)併用對雞隻中毒試驗=Toxicity of Combination of Tiamulin and Monensin in Chicken |
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作者 | 李新進; 李淑慧; 劉雅方; 楊喜金; | 書刊名 | 臺灣省家畜衛生試驗所研究報告 |
卷期 | 33 1997[民86.] |
頁次 | 頁87-92 |
分類號 | 437.717 |
關鍵詞 | 泰妙素; 孟寧素; 中毒; Tiamulin; Monensin; Toxicity; |
語文 | 中文(Chinese) |
中文摘要 | 為瞭解泰妙素與孟寧素以不同劑量之混合於飼料及飲水對雞隻之中毒情形,而從 事於本試驗。實驗分成六組飼餵 10 天,第一組為對照組飼餵不添加藥劑之空白飼料,第二 組至第四組於飼料中添加泰妙素及孟寧素分別為 100:50,200:100,250:120 ppm,第五 組及第六組於飲水中添加泰妙素及飼料中添加孟寧素添加比例分別為 200:200, 250:120 ppm。 結果顯示其臨床症狀投藥後第二天至第四天每組雞隻呈顯厭食,精神極度不良,雙翅 下垂,蹲下想睡,第五至第六天所有試驗雞組均拒食,大部份雞隻雙腳痳痺,蹲下或躺下睡 覺,第七至第九天精神慢慢恢復,雞隻少量進食,及可以站立,第十天全部試驗雞組精神及 飲食均恢復正常狀況,所有試驗雞於試驗中均未死亡。 解剖所見試驗各組之組織臟器並無明顯變化, 而組織病理之變化為添加泰妙素及孟寧素各 100 ppm 之試驗組,於心肌可見細胞呈空泡化,肌束間有炎症浸潤,心內膜有輕度至中度出 血,骨骼肌呈均質及顆粒化,並可見大量淋巴球浸潤於肌朿間。 |
英文摘要 | This experiment was carried out to study toxicity in chickens with different combination ratio of tiamulin (T) and monensin (M). Broilers were divided as follows: Group 1 to 4 were medicated fed with T and M in the ratio of 0:0,100:50,200:100, and 250:120 ppm in feeds for ten days, respectively. T in drinking water: M in feeds were in the ratio of 200:200 ppm and 250:120 ppm for group 5 and 6. Anorexia, depression, down wings, and drowsiness appeared on days 2 to 4 of administration in treated chicks. On days 5 to 6, eating nothing, leg paralysis, recumbent and drowsiness were prevalent, and severe, Chicks showed gradually recovery from Clinical signs on days 7 to 9, and became ormal on day 10. All broilers were alive in this experiment except for being sacrificed.No gross lesions were observed. Histopathological examination showed vacuolation in myocardium cell, inflammation cells infiltrated between myofibers, and light to medium level of hemolysis in endocardium. Besides, hyalinisation, granulation of skeletal muscle cell and a lot of lymphocytes infiltrated in the myofiber were also observed. |
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