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頁籤選單縮合
題名 | Effects of Veratrine and Paeoniflorin in Mice by Writhing Response Test=藜蘆鹼與芍藥苷對於鼷鼠扭體反應之影響 |
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作者 | 蔡輝彥; 林郁茲; 陳玉芳; 陳介甫; Tsai, Huei-yann; Lin, Yuh-tzy; Chen, Yuh-fung; Chen, Chieh-fu; |
期刊 | 中國醫藥學院雜誌 |
出版日期 | 19971200 |
卷期 | 6:3 1997.12[民86.12] |
頁次 | 頁221-226 |
分類號 | 414.5 |
語文 | eng |
關鍵詞 | 藜蘆鹼; 芍藥苷; 鼷鼠扭體反應; Veratrine; Paeoniflorin; Writhing response; |
中文摘要 | 於先前研究中,曾提出 veratrine 能起大鼠心房收縮,且此作用是經由活化鈉離 子及鈣離子管道, 而 paeoniflorin 抑制 veratrine 的收縮作用,與其阻斷鈣離子通道有 關。 在本研究中,以鼷鼠扭體試驗來探討 veratrine 及 paeoniflorin 在鎮痛的相互作用 ,結果顯示不同劑量的 veratrine (20,100,200,1000 ng) 經由腦室給藥,對鼷鼠扭體試驗 呈現劑量依存性的鎮痛作用。 不同劑量之 paeoniflorin (48,96,240,480 μ←g) 經由腦室 給藥, 亦對鼷鼠扭體試驗呈現劑量依存性的鎮痛作用。 當 paeoniflorin 及 veratrine (100 ng) 併用由腦室給與,發現 paeoniflorin 能夠逆轉 veratrine 對鼷鼠扭體試驗所致 之鎮痛作用。 |
英文摘要 | In a recent study, we postulated that contraction of rats' atria induced by veratrine might be attributed to stimulation of Na��-and Ca �� - ion channels, whilst the inhibition of such effect induced by paeoniflorin might be primarily related to blockade of Ca �� channel. In this study, we attempted to identify the interactive and antiociceptive effects of veratrine and paeoniflorin on the writching response test performed in mice. The result showed that both veratrine (20,100,200,1000ng, i.c.v.) and paeoniflorin (48,96,240,480 μ g. i.c.v.) exerted dose-related antinociceptive effects on the writhing response test. However, antinociceptive effect of veratrine (100ng, i.c.v.) was reversed by paeoniflor in (96 μ g, i.c.v.) when both agents were administered in combination. |
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