頁籤選單縮合
題名 | 無特定病原大小鼠自發性腫瘤之發生=The Occurrence of Spontaneous Tumors in SPF Rats and Mice |
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作者 | 梁鍾鼎; 劉振軒; 黃彥智; 龐飛; 陳憲全; 洪昭竹; | 書刊名 | 中華民國獸醫學會雜誌 |
卷期 | 23:6 1997.12[民86.12] |
頁次 | 頁531-545 |
分類號 | 437.24 |
關鍵詞 | 自發性腫瘤; 無特定病原大小鼠; Spontaneous tumors; SPF rats and mice; |
語文 | 中文(Chinese) |
中文摘要 | 於1994年7月至1996年12月期間,以病理學方法調查國科會國家實驗動物繁殖及 研究中心健康監測及淘汰之無特定病原大鼠及小鼠計 1666 頭,結果發現自發性腫瘤 48 頭 (2.9%)。 前述 48 例腫瘤中,小鼠佔 26 例 (54.2%) 而大鼠佔 22 例 (45.8%)。小鼠之品 種分佈為 ICR 10 例,AKR/J 8 例。 C3H/HeJ3 例, AKR/N, DBA/2N, DBA/2J, BALB/cByJ, BALB/cAnN 各 1 例。 另大鼠之品種為 SD7 例,Wistar 11 例,SHR/N3 例,Lew/SsN 1 例 。 性別分佈為母鼠佔 77.1%,公鼠佔 22.9%。若以年齡分佈為 26 週齡以下 12.5%,26-52 週齡 60.4%, 大於 52 週齡佔 27.1%。 腫瘤之發生部位以生殖系統 (包括乳腺 ) 佔最高 52%,造血系統 33.3%,及皮膚 6.25% 次之。所有腫瘤可分為 13 類,其中以淋巴瘤 14 例 (29.2%) 最多,其次為乳腺纖維腺瘤 10 例 (20.8%),再次為乳腺癌 8 例 (16.7%), 其他 依次為乳腺瘤 4 例 (8.3% ),基底細胞癌,組織細胞肉瘤及腎胚瘤各 2 例,而肺癌,乳腺 癌肉瘤,未分化腺癌,卵巢腺癌,許旺氏細胞瘤,纖維瘤各 1 例。[* 梁鍾鼎、劉振軒、黃 彥智、 龐飛、 陳憲全、 洪昭竹。 無特定病原大小鼠自發性腫瘤之發生。 中華獸醫誌 23(6):531-545,1997。* 聯絡人 TEL:02-7895569, FAX:02-7895588] |
英文摘要 | A total of 48 (2.9%) spontaneous tumors are diagnosed from 1666 rats and mice in the National Laboratory Animal Breeding and Research Center during a period from July 1994 to December 1996. The animals were raised in Specific Pathogen Free (SPF) condition. The 48 tumors diagnosed were 26 (54.2%) in the mice including 10 ICR, 8 AKR/J, 3 C3H and one each of AKR/N, DBA/2N, DBA/2J, BALB/c ByJ and BALB/c AnN; and 22(45.8%) in the rats including 7 SD, 11 Wistar, 3 SHR/N and 1 Lew/SsN. Sex predilection of these tumors were 77.1% (37/48) in females and 22.9% (11/48) in males. Age prevalence was 12.5% found in rodents under 26-week-old, 60.4% in 26 to 52-week-old and 27.1% over one-year-old. The tumors most commonly affect reproductive system (52%), hemopoietic system (33.3%) and integument (6.25%). The 48 tumor cases were classified in 13 diagnosis with the most three comomon occurences as lymphoma (14/29.2%), mammary gland fibroadenoma (10/20.8%), mammary gland adenocarcinoma (8/16.7%). The remainders were mammary gland adenoma (4), basal cell carcinoma (2), histiocytic sarcoma (2) , nephroblastoma(2), alveogenic carcinoma (1) , mammary gland carcinosarcoma(1) , mammary gland undifferentiated carcinoma (1), mammary gland carcinosarcoma(1), mammary gland undifferentiated carcinoma (1), ovarian, adenocarcinoma(1), schwannoma (1), and subcutaneous fibroma (1). These tumors were diagnosed morphologically based on histopathological, ultrastructurally and immunohistochemical investigations.[*Liang CT, Liu CH, Huang YT, Pang Victor F, Chen Hans HC and Hong CC. The occurrence of spontaneous tumors in SPF rats and mice. J Chin Soc Vet Sci 23(6) : 531-545, 1997.*Corresponding author TEL: 02-7895569, FAX:02-7895588] |
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