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題 名 | Serum Pepsinogen Ⅰ,Ⅱ, and the Ratio of Pepsinogen Ⅰ/Pepsinogen Ⅱ in the Intestinal Metaplasia of the Stomach=血清中Ⅰ、Ⅱ型胃蛋白酵素原及Ⅰ型/Ⅱ型胃蛋白酵素原比值與胃粘膜小腸化生的關係 |
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作 者 | 張史雍; 吳明賢; 孫家棟; 王世晞; 楊增慧; 劉增應; 林肇堂; | 書刊名 | 中華民國消化系醫學雜誌 |
卷 期 | 14:1 1997.03[民86.03] |
頁 次 | 頁18-23 |
分類號 | 415.145 |
關鍵詞 | 小腸粘膜化生; Ⅰ型胃蛋白酵素原; Ⅱ型胃蛋白酵素原; 萎縮性胃炎; Intestinal metaplasia; Pepsinogen Ⅰ; Pepsinogen Ⅱ; Atrophic gastritis; |
語 文 | 英文(English) |
中文摘要 | 本研究的目的在評估血清中胃蛋白酵素原與胃粘膜小腸化生的關係。研究對象對 245 位馬祖居民,研究方法為前瞻性篩計劃。我們用泛內視鏡檢切片的組織學檢查來診斷胃 粘膜小腸化生。結果發現,其中 58 人 (24.7 % ) 有小腸化生。在進行內視鏡檢查時之前 進行抽血,並用放射免疫分析法測量血清胃蛋白酵素原,得到的結果是:沒有小腸化生的居 民 (177 人 ), 血清中平均之 I 型胃蛋白酵素原為 73.7 ± 37.6ng/ml,而有小腸化生者 (58 人 ) 則為 62.1 ± 38.4ng/ml,此二者之差別在統計上為有意義 (P<0.05)。無小腸化 生者之血清 II 型胃蛋白酵素原為 12.1 ± 7.2 ng/ml, 有小腸化生者則為 11.8 ± 6.7 ng/ml,統計學上無顯著差別 (p>0.05)。I 型╱ II 型胃蛋白酵素原的比值,無小腸化生者 為 7.3 ± 3.7,有小腸化生者為 5.8 ± 3.2, 兩者在統計學上呈有意義的差別 (P<0.01) 。綜而言之,本研究發現小腸化生者有較高之幽門螺旋桿菌血清感染率及年齡較大,並且有 明顯較低的血清 I 型胃蛋白酵素原濃度及 I 型╱ II 型胃蛋白酵素原之比值。 |
英文摘要 | The aim of this study was to evaluate the relationship between serum pepsinogens and intestinal metaplasia (IM) of the stomach. Two hundred and thirty-five adult residents in Matsu were enrolled in a prospective screening program. Panendoscopy and histologic examination of biopsies of the stomach were performed for detecion of IM. Fifty-eight (24.7%) of 235 enrolled subjects were found to have IM in their stomach. Serum pepsinogen levels were determined concomitantly just before endoscopic examination. The serum levels of PGI and PGII were measured by a radioimmunoassay. The mean serum PGI level was 73.7 ± 37.6 ng/ml (mean ± S.D.) in subjects without IM, in contrast to 62.1 ± 38.1 ng/ml in subjects with IM. Statistically significant differences (p<0.05) existed between these two groups. The mean serum PGII level in subjects without IM (12.1 ± 7.2 ng/ml) was not different from that of IM (11.8 ± 6.7 ng/ml), (p>0.05). Patients without IM had a significantly higher value of PGI/PGII ratio (7.3 ± 3.7) than that of IM (5.8 ± 3.2) (p<0.05). It was concluded that subjects with IM had a higher H. pylori seroprevalence rate and an older age. The serum PGI levels and PGI/PGII ratios were lower in subjects with IM. |
本系統中英文摘要資訊取自各篇刊載內容。