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題 名 | Short-term Effect of Bilateral Subthalamic Stimulation for Advanced Parkinson's Disease=雙側視丘下核刺激治療嚴重型帕金森氏病之短期術後成效 |
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作 者 | 陳瓊珠; 李石增; 吳禹利; 陳啟仁; 陳明岐; 陸清松; | 書刊名 | 長庚醫學 |
卷 期 | 26:5 2003.05[民92.05] |
頁 次 | 頁344-351 |
分類號 | 415.83 |
關鍵詞 | 視丘下核; 深部腦刺激; 帕金森病; Subthalamic nucleus; Deep brain stimulation; Parkinson's disease; |
語 文 | 英文(English) |
中文摘要 | 背景:視丘下核的過度活化被認為是帕金森氏病的基本病理機轉。用深部腦刺激術來抑制該核之過度活性。可能可以調整皮質~紋狀體~視丘迴路之功能進而改善帕金森氏病的症狀。 方法:本研究包含7名嚴重的帕金森氏病人。皆有運動起伏或亂動症等併發症。將一永久性之刺激電極植入病人二側大腦視丘下核,並以長久刺激。一系列的臨床評估在術前及術後6個月依有藥效,及有無刺激等情況分別實施。所得之分數以統計、分析。 結果:在有藥效及無藥效的狀況下,視丘下核深部腦刺激皆明顯改善病人之活動。在無藥效期之比較,深部腦刺激在術後6個月的UPDRS運動評估項目改善達53%,其他顫抖,僵硬,行動緩慢,步態及姿勢穩定Hoehn與Yahr病期等皆有改善,Schwab與England生活指數改善達205.6%類似改善亦見於有藥效期。在深部腦刺激下有部分病人產生暫時性的舞蹈症、情緒變化及眼痙攣症等,此外並未發現嚴重或永久之併發症。 結論:雙側視丘下核深部腦刺激有效改善帕金森病人於有藥效期及無藥效期之動作症狀,其中不只改善顫抖、僵硬、動作緩慢及步態穩定更包括因藥劑量減少而改善之亂動情形及精神症狀。 |
英文摘要 | Background: Subthalamic nucleus (STN) byperactivity is a pathophysiological phenomenon of Parkinson’s disease (PD). Inhibition of this hyperactivity by chronic deep brain stimulation (DBS) can possibly reset the aberrant function of the cortico-striato-thalamal circuit and improve the parkinsonian symptoms. DBS was introduced as a safe and alternative way of performing functional stereotaxic surgery for treating PD. Methods: Seven advanced PD patients with complicated motor fluctuations and dyskinesia were enrolled in the study. A quadripolar electrode was bilaterally installed in the STN. Patients were evaluated before and 6 months after implantation using a battery of clinical assessments, including the motor score of the unified Parkinson’s disease rating scale (UPDRS), modified Hoehn and Yahr (HY) staging , and the Schwab and England activities of daily living scale (SEADL). Preoperative baseline evaluations included both “off-medication” periods and “on-medication” periods, while postoperative evaluations included a cross-over of the above 2 periods with and without DBS. Results: The motor disability, HY staging, and SEADL all significantly improved in both the off- and on-medication periods 6 months after STN DBS. Compared to the baseline off-medication score, a significant improvement was found in the UPDRS motor and other subscores including tremors, rigidity, and bradykinesia. The SEADL score showed a great improvement of 205.6%. Ballism/chorea, mood changes, and blepharospasm may have been induced by DBS. Neither serious nor permanent side effects appeared. Conclusions: Bilateral STN DBS improved the motor symptoms in advanced PD patients in both the off- and on-medication periods. They showed improvements not only in motor disabilities of tremors, rigidity, bradykinesia, and postural and gait instability, but also in levodopa-related dyskinesia and psychosis. |
本系統中英文摘要資訊取自各篇刊載內容。