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題名 | 帕金森病患者鎝-99m-TRODAT-1多巴胺轉運體SPECT初步臨床應用研究=Preliminary Clinical Application of Dopamine Transporter Imaging with Technetium-99m-TRODAT-1 and SPECT in Parkinson's Disease |
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作 者 | 吳錦昌; 羅蔚峰; 方平; 劉增禮; 唐軍; 王峰; 包仕堯; | 書刊名 | 核子醫學雜誌 |
卷期 | 14:2 2001.06[民90.06] |
頁次 | 頁97-101 |
分類號 | 415.83 |
關鍵詞 | 鎝-99m-TRODAT-1; 多巴胺轉運體; 腦; 帕金森病; Technetium-99m; SPECT; Dopamine transporter; Brain; Parkinson's disease; |
語文 | 中文(Chinese) |
中文摘要 | 目的:評估鎝-99m-TRODAT-1多巴胺轉運體(DAT)SPECT診斷帕全森病及其嚴重程度(H/Y分級)的價值。 方法:正常對照組22例,帕金森病患者27例 (H/Y 1~4級)。靜脈注射鎝-99m-TRODAT-1 2~3小時後進行腦多巴胺轉運體SPELT,並應用ROI技術計算紋狀體;小腦放射活性比值(ST/CB)。 結果:與正常對照組比較,PD患者紋狀體內鎝-99m-TRODAT-1積聚顯著下降,且ST/CB比值隨著病情嚴重程度的加重而減小。 結論:鎝-99m-TRODAT-1多巴胺轉運體SPECT有助於瞭解PD患者紋狀體內多巴胺轉運體喪失情況,並發現與H-Y級別密切相關。 |
英文摘要 | Objective: The aim of the present study was to evaluate the usefulness of 99mTc-TRODAT-1 as an imaging agent for measuring changes in transporter concentrations in Parkinson's disease (PD) and correlate the findings to the severity of the disease (Hoehn and Yahr scale, H/Y). Methods: Twenty-two healthy volunteers and 27 patients with PD of H/Y stage I- IV were investigated. Acquisitions were performed 2~3 h postinjection of 99mTc-TRODAT-1. ROIs were drawn over the striatum and the cerebellum. The ratios of striatum-to-cerebellum (ST/CB) were calculated. Results: The striatal uptake of 99mTc-TRODAT-1 showed a significant decrease in patients with PD in comparison with healthy volunteers and the ST/CB ratios was closely related to the stage of PD. Conclusion: The present study demonstrates that it is possible to visualize and quantify the changes of dopamine transporters in striatum in PD patients using 99mTc-TRODAT-1 and SPECT with good correlation to H/Y stage. |
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