查詢結果分析
來源資料
頁籤選單縮合
題名 | Short-Term Effects of Simvastatin in Chinese Patients with Primary Hypercholesterolemia=Simvastatin治療中國人原發性高膽固醇血症之短期效果 |
---|---|
作者 | 周湘臺; 林楨智; | 書刊名 | 中國醫藥雜誌 |
卷期 | 2:4 1997.12[民86.12] |
頁次 | 頁203-207 |
分類號 | 415.38 |
關鍵詞 | 原發性高膽固醇血症; Simvastatin; Primary hypercholesterolemia; |
語文 | 英文(English) |
中文摘要 | 本研究為一單盲實驗,為期八週,目的存評估Simyastatin治療中國人斥發性高膽固醇血症之安全性、耐受性及療效,以38位原發性高膽固醇血症患者為研究對象,其中21位為男性,17位為女性,年齡由34歲至70歲,每位血清膽固醇都高過240mg/dL。患者隨機分成兩組,一為Simvastatin組內含20人,另一為Placebo組內含18人。患者進入藥物治療期前,都先施以標準降脂飲食上停用任何降脂藥物,至少六週。血清脂質包含總膽固醇、三酸甘油脂、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、前脂蛋白A1及前脂蛋白B,在開始使用藥前,用藥第四週末、第八週末,部分別測定之。另CK、SGPT、SGOT及BUN,血液常規也分別同時測定。 經八週的Simvastatin治療,Simvastatin組血凊膽固醇下降25%,三酸甘油脂下降18%,低密度脂蛋白膽固醇下降29%,前脂蛋白B則下降39%,兩例服藥後有疲倦及腹部不適感,一例之CK上升,無患者有SGPT、SGOT、BUN或血液常規產生明顯改變。 結論為Simvastatin用來短期治療中國人原發性高膽固醇血症,可有效降低血清總膽固醇、低密度脂蛋白膽固醇、三酸甘油脂及及前脂蛋白B,而且副作很少。 |
英文摘要 | A single-blind, eight week study to evaluate the safety, tolerability and efficacy of simvastatin in the treatment of primary hypercholesterolemia was performed. This study included 38 patients (21 male and 17 female), ages from 34 to 70 years old with primary hypercholesterolemia defined by serum total cholesterol higher than 240 mg/dl without secondary causes. Patients were randomly allocated into two groups; the simvastatin group included 20 patients treated with simvastatin 10 mg QN and the placebo group included 18 patients treated with placebo. All patients started(or continued) a standard lipid lowering diet and discontinued any lipid lowering drugs at least six weeks prior to the start of the study. Serum levels of total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apolipoprotein A1 (Apo Al) and apolipoprotein B(Apo B) were measured before administration of simvastatin or placebo. Follow-up data were obtained 4 and 8 weeks after initiation of simvastatin or placebo treatment. Creatine kinase (CK), serum glutamic oxaloacetic transaminase (SCOT), serum lutamic pyruvic transaminase (SGPT) and blood urea nitrogen (BUN) were measured at 0, 4 and 8 weeks to assess possible side effects of simvastatin. As compared with baseline, at the end of the 8-week treatment period TC was reduced by 25%, TG 18%, LDL-C 29%, and Apo B 39 % in simvastatin group patients. Fatigue and abdominal discomfort were reported in two patients. CK elevation was found in one patient. SCOT, SGPT and BUN increase were observed in none of the patients. We concluded that short-term therapy with simvastatin is effective in reducing serum total cholesterol, LDL-cholesterol, triglycerides and apolipoprotein B levels with few side effects in Chinese patients with primary hypercholesterolemia. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。