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題 名 | Dentate Hilar Cell Damage in Electric Stimulation-Induced Limbic Status Epilepticus=電誘發之緣系癲癎重積造成的海馬齒迴門神經元死亡 |
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作 者 | 謝佩圜; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 13:11 1997.11[民86.11] |
頁 次 | 頁671-676 |
分類號 | 415.932 |
關鍵詞 | 電誘發; 癲癎重積; 海馬; 齒迴門神經元; Status epilepticus; Excitotoxicity; Dentate hilus; |
語 文 | 英文(English) |
中文摘要 | 顳葉癲癇病人腦子的海馬結構有神經元死亡與苔狀纖維異常分枝,然而這些現 象發生的機轉仍不清楚。齒迴門神經元死亡可能造成苔狀纖維異常分枝,也可能和顳葉癲癇病人海馬結構的異常興奮性有關。本研究用電刺激老鼠引發緣系癲癮重積,探討癲癇時間長短與齒迴門神經元死亡的關係。記錄兼刺激用之電極以立體定位手術置於大白鼠右側杏仁核。術後8-14天測定後續放電閾值 (afterdischarge thresh-old),隔天用電刺激引發緣系癲癇重積,並於0.5小時 (n=6)、1小時 (n=6)、2至4小時 (n=14) 給予腹腔注射 Diazepam (10mg/kg) 使癲癇終止,18小時後以灌流固定術犧牲老鼠。Sham operation組 (n=4) 接受相同之電極植入手術但未受電刺激。Naive對照組 (n=10) 未接受手術。為觀察腹側海馬齒迴門神經元死亡情形,於interauralline+2.66mm處取5μm之水平石蠟切片,以acidfuchsin/cresylviolet染色,死亡神經元之細胞質呈紅色,正常神經元之尼氏體 (Nissi body) 則呈淡藍色。每隻老鼠以連續三張切斤求右側齒迴門之死亡神經元平均數目。資料以Mann-Whitney U test分析。結果顯示sham operation與0.5小時之癲癇不會造成齒迴門神經元死亡,1小時以上則有明顯的死亡。此神經元死亡與電刺激時間長短、電流強弱、刺激強度 (電流乘以時間)、及癲瘸行為表現無關。以本動物模式再深入研究,可望進一步瞭解癲癇重積之病理機轉並改善臨床醫療水準。 |
英文摘要 | The study explored for the first time the quantitative dentate hilar cell damage In relation to the duration of Iambic status epilepticus (SE) Induced with electric stimulation on naive rats. SE was Induced In adult S-D rats with electric stimulation delivered through a stimulating/recording electrode targeted at the right amygdata. Once SE was established, no further stimulation was given. The rats were treated with diazepam at various times to stop SE, and perfused 18 hours later. Naive and sham operated rats served as controls. Horizontal paraffin sections at the level of the ventral hippocampus were stained with acid fuchsin/cresyl violet. Irreversibly damaged neurons In the right dentate bilus were counted. Neuronal damage was absent with sham operation (n=4, p > 0.05) and 30-min SE (n=4, p > 0.05), but it became significant with 1 hour (n=6, p < 0.05) and longer durations (n=14, p < 0.05) of SE, compared with the naive controls (n=10). The severity of SE-Induced neuronal damage was not related to the current Intensity, Induction time, stimulation Intensity, or number of class 3-5 seizures. We demonstrate for the first time the relation between seizure duration and the severity of dentate bilar cell damage In Iambic SE Induced by electric stimulation of naive rats. Further study of this model mav elucidate the pathophystology of SE and Improve patient care. |
本系統中英文摘要資訊取自各篇刊載內容。