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題 名 | Glucocorticoids and Aging=腎上腺糖皮醇與老化 |
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作 者 | 王錫崗; 駱明潔; 高美媚; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 96:10 1997.10[民86.10] |
頁 次 | 頁792-801 |
分類號 | 415.934 |
關鍵詞 | 腎上腺糖皮醇; 老化; ACTH; Corticotropin-releasing hormone; Hippocampus; Glucocorticoid receptor; Stress; |
語 文 | 英文(English) |
英文摘要 | In this review we analyze the morphologic changes, hypothalamic- pituitary- adrenal (HPA) axis functions, glucocorticoid (GC) receptors, and steroidogenic enzyme activities in both animals and humans during aging. In rodent studies, older animals tend to show:1)hypertrophy of adrenal zona fasciculata (ZF) cells: 2)neuronal loss in the hypothalamic area; 3)loss of GC receptors in the hippocampus; 4)raised circulating adrenocorticotropic hormone (ACTH) and GC levels, and increased release of corticotropin-releasing hormone from the hypothalamus; 5)reduced sppression of endogenous GC secretion after administration of dexamethasone; 6)decreased attenuation of response to chronic stress; and 7)increased activity of P450scc and 21-hydroxylase. According to the GC cascade hypothesis, stress and GCs facilitate the aging process in in rats. Stress induces downregulation of GC receptors in the hippocampus, then impairs GC feedback on stress-induced HPA axis activation. Finally, an increase in the basal level of corticosterone and extended GC secretion following stress occurs. Because activation of the hippocampus decreases HPA axis function, the unrestrained elevation of GC concentration and the reduction in the level of GC receptors in the hippocampus may gradually weaken the feedback mechanisms and halt the response to stress. In humans, there are conflicting reports of HPA axis function during aging, so it is difficult to make a final conclusion regarding the relationship between aging and HPA axis function. |
本系統中英文摘要資訊取自各篇刊載內容。