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題 名 | 激性腺素釋放素類似物之合成及應用評估=Synthesis and Biological Application of an Analog of Gonadotropin-Releasing Hormone (GnRH) Modified in Position 6 |
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作 者 | 施英隆; 蔡新; 賈玉祥; 黃錦源; 戈定軍; 陳賜鈺; | 書刊名 | 中國畜牧學會會誌 |
卷 期 | 26:4 1997.12[民86.12] |
頁 次 | 頁419-428 |
分類號 | 437.654 |
關鍵詞 | 激性腺素釋放素; GnRH類似物; 女豬發情; 排卵; Gonadotropin-releasing hormone; GnRH analog; Ovulation; Heat; Corpus luteum formation; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究中我們利用固相胜�韟X成技術合成了激性腺素釋放素(GnRH)之類似物(D- Ala �� GnRH),pGlu-His-Trp-Ser-Tyr-(D)Ala-Leu-Arg-Pro-Gly-NH �砥A 由於該類似物係 將自然 GnRH 對胜�齘t不穩定之第 6 個胺基酸置換為 D-Ala, 如此增強其對胜�齘t之抗性 而分解減少,因此激性腺素之釋出活性增加 3~5 倍。我們亦將合成之 GnRH 類似物 (D-Ala �� GnRH) 實際現場應用於誘發女豬發情、排卵之實驗。 結果顯示 10 頭處理之女豬中,有 6 頭女排卵, 唯僅有 3 頭有發情徵狀, 其他 3 頭發情狀況不明顯,至於未以 D-Ala �� GnRH 處理之對照組,則無任何一頭有發情、排卵之現象,故所合成之 D-Ala �� GnRH 對未 發身女豬之排卵雖具效果,然發情率與排卵數均低,在現場之應用尚未能達完全滿意。然而 與自然序列之 GnRH 比較, 我們之結果已顯示 D-Ala �� GnRH 在活體內之應用效果應比自 然序列之 GnRH 比較,我們之結果已顯示 D-Ala���詖nRH 在活體內之應用效果應比自然序 列之 GnRH顯著。 |
英文摘要 | D-Ala�� GnRH (pGlu-His-Trp-Ser-Tyr-(D)Ala-Leu-Arg-Pro-Gly-NH2) is a highly potent analog of gonadotropin- releasing hormone, and its LH-releasing activity has been shown to be 3-5 fold greater than that of GnRH itself. Here we synthesized this analog with solid phase methodology and confirmed its LH-releasing activity. In order to evaluate its biological application, field trials were also conducted on female porcines to test its effect on ovulation and heat induction as well as corpus luteum formation. The results showed that D-Ala �� GnRH was effective in the induction of ovulation; however, the number of eggs produced and the heat induction were not as significant as expected. Nevertheless, the results indicated that the potency of in vivo application of the D-Ala �� GnRH was greater than that of the GnRH itself. |
本系統中英文摘要資訊取自各篇刊載內容。