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題 名 | 細菌之核苷核糖化毒素:綠膿桿菌外毒素A=ADP-Ribosylating Bacterial Toxins: Pseudomonas Exotoxin A |
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作 者 | 陳作琳; 林立中; 黃昭蓮; 林嘉伯; | 書刊名 | 藥物食品分析 |
卷 期 | 4:2 1996.06[民85.06] |
頁 次 | 頁107-114 |
分類號 | 414.83 |
關鍵詞 | 核苷核糖化; 細菌毒素; 綠膿桿菌外毒素A; ADP-ribosylation; Bacterial toxins; Pseudomonas exotoxin A; PEA; |
語 文 | 中文(Chinese) |
英文摘要 | It is well known that a number of toxins produced by bacteria exert their action by ADP-ribosylating reaction to certain proteins which are essential for normal eukaryotic cellular functions. Most of these toxins are composed of two moieties, A and B. The B moiety mediates the binding to the specific receptor on the surface of toxin-sensitive cells, while the A moiety is responsible for the enzymatic ADP- ribosylating activity. Pseudomonas exotoxin A (PEA) is the most toxic component of the extracellular products produced by Pseudomonas aeruginosa. The three domain model of PEA has been well established : domain I, domain II, and domain III exerting binding, translocation, and ADP-ribosylating activities, respectively. Because of the cytotoxic ADP-ribosylating nature of PEA, it has been suggested as a good candidate in the preparation of immunotoxins. In this minireview article, we discuss the structure and function of the bacterial ADP-ribosylating toxins including PEA and compare the differences particularly between PEA and other valevant toxins. |
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