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題 名 | Retinopathy of Prematurity in Very-Low-Birthweight Neonates: Epidemiology and Risk Factors=極低出生體重早產兒的視網膜病變:流行病學與危險因子分析 |
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作 者 | 滕儒錚; 吳宗瑾; 鄒國英; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷 期 | 38:5 民86.09-10 |
頁 次 | 頁370-374+404 |
分類號 | 417.517 |
關鍵詞 | 早產兒視網膜病變; 極低出生體重; 閾症; Retinopathy of prematurity; Very-low-birthweight; Threshold disease; |
語 文 | 英文(English) |
英文摘要 | 在回溯性的研究中共有 143 位極低出生體重兒被研究,其中 138 位有完整的資 料可供整理,他們均在出生後四到六週內由接受過視網膜專門訓練的眼科醫師檢查眼底。每 個個案均有三十四項產前與產後的重要因素被登錄當成自變項,以視網膜病變的發生、視網 膜病變的嚴重程度及閾值視網膜病變作為應變項來分析。 我們發現視網膜病變的發生率為 18.8%, 出生體重低於 1000 公克的早產兒的發生率為 44.9%,閾值視網膜病變的發生率為 3.6%,所有閾值視網膜病變都發生在出生體重低於 1000 公克的早產兒。在多變項分析中使 用持續性呼吸道正壓治療的天數與視網膜病變的發生有關;使用持續性呼吸道正壓治療的天 數、血清總膽紅素值及血清直接膽紅素值與視網膜病變的嚴重度有關;細菌性敗血症與閾值 視網膜病變的發生有關。在我們的研究中發現,防範細菌性敗血症的發生可能是預防閾值視 網膜病變的最好方法。 t cases were survived for more than 28 days with their eyes been checked. Twenty-six (18.8%) of them developed ROP. The prevalence of stage I was 2.2% (3/138), stage Ⅱ was 3.6% (5/138), stage Ⅲ was 12.3% (17/138), and stage V was 0.7% (1/138). Threshold disease, stage 3 (+) and above, was found in 5 cases (3.6%). Seventeen variables were found to be correlated with the development of ROP. Only the duration of continuous positive airway pressure (CPAP) was significntly correlated to the development of ROP in multivariate logistic regression. Fifteen variables were correlated with the severity of ROP, but only peak direct bilirublin level, peak total bilirubin level and duration of CPAP could entered multiple stepwise linear regression. Thirteen variables were correlated with the development of threshold ROP. but only episodes of septicemia enter the multivariate logistic regression. We postulate that the longer duration of CPAP in ROP cases may reflect the severity of apnea and episodes of hypoxic attacks. Reducing episodes of apnea may prevent the development of ROP. The number of episodes of septicemia was the only significant variable for threshold ROP so that infection control is important for the prevention of threshold disease. |
本系統中英文摘要資訊取自各篇刊載內容。