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頁籤選單縮合
題名 | Influence of Maternal Age and Weight on Second-Trimester Serum Alpha-Fetoprotein, Total and Free Beta Human Chorinic Gonadotropin Levels=母親年齡和體重對懷孕中期血清甲型胎兒蛋白、全人類絨毛膜性腺激素和游離型貝它人類絨毛膜性腺激素濃度之影響 |
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作 者 | 徐振傑; 謝燦堂; 宋永魁; | 書刊名 | 長庚醫學 |
卷期 | 20:3 1997.09[民86.09] |
頁次 | 頁181-186 |
分類號 | 417.34 |
關鍵詞 | 母親體重; 母親年齡; 甲型胎兒蛋白; 全人類絨毛膜性腺激素; 游離型貝它人類絨毛膜性腺激素; 唐氏症; Maternal weight; Maternal age; Alpha-fetoprotein; AFP; Human chorionic gonadotropin; hCG; Free beta human chorionic gonadotropin; Free β-hCG; Down's syndorme; |
語文 | 英文(English) |
中文摘要 | 背景 :本研究主要目的在於評估母親年齡和體重與懷孕中期血清甲型胎兒蛋白、 全人類絨毛膜性腺激素、和游離型貝它人類絨毛膜性腺激素濃度之關係。方法: 我們隨意收 集 419 個懷孕 14 至 21 週的正常單胞胎台灣婦女的血清標本, 予以分析其血清甲型胎兒 蛋白、全人類絨毛膜性腺激素、和游離型貝它人類絨毛膜性腺激素濃度。母親年齡的定義是 以預產期時的年齡為計算; 母親體重則是以抽血時的體重為主。我們使用線性迴歸和相關係 數來探討母親年齡和體重與血清標誌濃度之關係。結果: 中國婦女在懷孕中期的平均體重約 55.3 公斤, 本文發現母親體重與血清標誌濃度略呈負相關,亦即體重較重的婦女其血清標 誌濃度較低; 反之,體重較輕的婦女其血清標誌濃度偏高。母親年齡與血清標誌濃度並無明 顯相關,但母親年齡和體重則略至正相關,亦即年齡較高的婦女其體重似乎也較重。 結論: 因為母親體重會影響血清標誌濃度,所以母親體重的校正可改善母血篩檢唐氏症的品質。 |
英文摘要 | Backagound:The purpose of this study was to assess the relation of maternal age and weight on the maternal serum alpha-fetoprotein (AFP), total human chorionic gonadotropin (hCG) and free β -hCG levels during the second trimester. Methods: We collected 419 serum samples from normal singleton pregnancies to assay serum marker levels of AFP, total hCG and free β -hCG between 14 and 21 weeks of gestation. Maternal age at the day of delivery and maternal weight at the time of sam- pling were recorded in all cases. The relationship between maternal weight and multi- ple of the median (MoM) levels of serum markers was analysed by regression models. Results: There was an inverse trend in median MoM levels of serum markers in relation to maternal weight. No significant association between maternal age and serum marker levels was found. Conclusion: Because of its impact on serum marker levels, weight correction may be mandatory for further refinement in the maternal serum screening for Down's syn- drome. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。