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題 名 | 蛋白質結構之電腦預測=Introduction to Protein Structure Predictions |
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作 者 | 鄒文雄; 黃明經; | 書刊名 | 化學 |
卷 期 | 55:3 1997.09[民86.09] |
頁 次 | 頁101-109 |
專 輯 | 生物物理化學 |
分類號 | 346.77 |
關鍵詞 | 蛋白質序列與結構; 同源模擬法; 穿針引線法; "從頭算起"法; Protein sequence/structure; Homology modeling; Threading; AB inito method; |
語 文 | 中文(Chinese) |
中文摘要 | 目前已發現的蛋白質數目遠超過已被解出結構之蛋白質數目,這個現象使得序 列與結構之間有一大落差。要縮小這個落差,除了可用X-射線繞射法與NMR光譜法來解析 蛋白質結構外,運用電腦來預測蛋白質結構已成為未來的趨勢。此篇將介紹三種預測策略 (同源模擬法,穿針引線法,與"從頭算起"法)的原理、方法學、應用及注意事項,並舉 文獻上相關的個例加以闡述。一些有用的網址也隨附在後。 |
英文摘要 | The number of known protein sequences outstrips that of resolved protein structures. In complement to structure determination methods such as X-ray crystallography and NMR, computer predictions are becoming increasingly powerful in closing the sequence-structure gap. In this article, three prediction strategies, homology modeling, threading and ab initio methods, are introduced and illustrated with examples reported in the literature by leading researchers in this field. The basic principles, methodologies, scope of application and caveats of the three strategies are discussed. A number of useful web sites are also listed. |
本系統中英文摘要資訊取自各篇刊載內容。