頁籤選單縮合
題 名 | Melatonin(褪黑激素)的急性毒性嚴重嗎?=Acute Overdosage of Melatonin-is it a Serious Problem? |
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作 者 | 楊振昌; 李瑞瑛; 鄧昭芳; | 書刊名 | 內科學誌 |
卷 期 | 8:2 1997.06[民86.06] |
頁 次 | 頁88-95 |
分類號 | 418.27 |
關鍵詞 | 苯重氮基鹽類安眠藥; 失眠; 時差; 褪黑激素; Benzodiazepines; Flumazenil; Insomnia; Jet lag; Melatonin; |
語 文 | 中文(Chinese) |
中文摘要 | Melatonin (褪黑激素)為松果體分泌的荷爾蒙,臨床上可用 來作為調整時差及輔助睡眠。Melatonin雖然在臺灣已逐漸流行,但其臨 床毒性目前仍不清楚。為瞭解臺灣地區有關因melatonin而引起的毒性症 狀及其處理,吾人謹回顧了臺北榮民總醫院毒藥物防治諮詢中心過去因服用 melatonin而諮詢的個案。自民國85年2月至86年4月間,共有39 名 因melatonin過量而諮詢的個案。在扣除10名基本資料不全或服用劑量 未知的個案後,其他29名個案之症狀,主要以輕度中樞神經抑制的嗜睡、 頭暈及全身虛弱為主;有3人雖服用過量melatonin,但並未產生任何症 狀。對於melatonin過量的治療,主要以觀察及支持療法為主;有4人曾 使用flumazenil,且其中3人反應良好。根據本研究顯示,melatonin 的毒性不高,而絕大多數患者的症狀皆在1-2天內完全消失,且未有任何 後遺症。 未有任何後遺 症。 |
英文摘要 | Melatonin, a hormone secreted from the pineal gland,has been used in the clinical grounds of jet lag and insomnia. Although it is gaining its popularity in Taiwan, its toxic effect remains unclear. To better understand the adverse effects or toxicity of melatonin, we conducted a retrospective study concerning patients with melatonin overdose or misuse reported to the poison center operated by the Veterans General Hospital-Taipei. Totally, 29 patients with melatonin related toxic effects were recorded in the last 15 months. The major manifestations of melatonin overdose were symptoms of mild neurological depression, e.g. drowsiness, dizziness, and general weakness. However, 3 patients with melatonin overdose were asymptomatic. Treatment of melatonin overdose were mainly supportive. Flumazenil had been used in 4 patients with moderate drowsiness, showing a good response in 3 of them. As most patients in this study recovered completely within 1 to 2 days without any sequelae, the toxicity of melatonin seems to be low. (J Inter Med Taiwan 1997;8:88-95) |
本系統中英文摘要資訊取自各篇刊載內容。