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題名 | 史蒂夫-強生症候群伴隨齒列嚴重發育缺陷--病例報告=Severe Dental Developmental Defects Associated with Stevens-Johnson Syndrome: Case Report |
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作者 | 周明嫣; 蔡宗平; 陳朝寶; 潘惠玲; | 書刊名 | 中華民國牙周病醫學會雜誌 |
卷期 | 2:2 1997.06[民86.06] |
頁次 | 頁77-85 |
分類號 | 416.94 |
關鍵詞 | 史蒂夫-強生症候群; 牙根發育異常; 先天性缺牙; Stevens-Johnson syndrome; Abnormal root development; Congenitally missing tooth; |
語文 | 中文(Chinese) |
中文摘要 | 史蒂夫-強生症候群(SJS)是由大皰性多形紅斑廣泛侵皮膚、口腔、眼睛、生殖器 官等處黏膜之嚴重病變。 此疾病於任何年齡層均可能發生,尤好發於二十 ~ 四十歲健康年 輕人,男生略多於女生。可能併發承化道、腎臟、心臟等其他問題而有致命危險。SJS 於口 腔上主要引起嘴唇潰瘍結痂、黏臘起水泡繼而破掉、糜爛等表徵,進一步因疼痛導致進食、 咀嚼、吞嚥困難。 自 De Man 於 1979 年首先提出一病例報告懷疑 SJS 可能會影響�琱�齒 列發育之後,至今僅有四例相關的病例。 本病例為一位七歲女孩, 於二歲四個月大時罹患 SJS,具有雙眼角膜混濁、聽力喪失、全身皮膚遺留患病疤痕、手指甲缺失等後遺症,口腔 並伴隨全口齒齦炎,乳牙、�琱�牙根短小及八顆恆牙牙胚根短小及八顆恆牙牙胚缺失之情形 。本例與過去文獻相較,發病年齡最小,齒列受犯之情形最為嚴重,除恆齒牙根變短,乳齒 牙根也變短,並有多顆永久牙牙胚缺失之情形。 本報告就齒列發育異常與 SJS 發病之相關 作一探討,顯示在牙胚發育初期受到 SJS 侵犯之患者,其受影響之程度,可能包括牙根短 小甚或牙胚缺失,並提出在口腔治療之考慮及追蹤情形。 |
英文摘要 | Stevens-Johnson Syndrome (SJS) is a severe disease caused by Erythema Multiforme Major (EMM) affecting skin and mucosa of mouth, eyes and genital organs. SJS may occur at any age but is more likely to affect young healthy male between age 20 to 40. Death is possible from complications in gastrointestinal tract, kidney, heart or other vital organs. The oral manifestations of SJS are oral ulcers, scarring, mucosal blisters and necrosis. The episode of SJS may cause difficulties in eating, chewing and swallowing. Assocation of SJS and abnormal root development was first suggested by De Man in 1979. Only three similar cases were reported since then. This case report persented a seven-year-old girl who was affected with SJS at the age of two years and four months. complications of SJS included milky corneas on both eyes, hearing loss, scareed skin on whole body and finger nails defects. Oral examination showed short-rooted primary and permanent teeth, and missing of eight permanent tooth germs. In all cases reported, the present case was suffered by SJS at the youngest age. The development of both dentitions was affected. The relationship between developmental defects and SJS was discussed and considerations in the long-term oral treatment was presented. The report suggested that occurrence of SJS in early stage of dental development may caused shortening of developing roots and destruction of tooth germs. |
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