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題名 | Light-Induced Fluorescence Spectroscopy to Differentiate Benign and Malignant Uterine Cervical Lesions=子宮頸良性及惡性病變螢光光譜探討 |
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作 者 | 陳進庭; 黃千祝; 陳瑞堅; 林育弘; 江惠華; 王智昱; 李玉珊; 周松男; | 書刊名 | 臺灣醫學會雜誌 |
卷期 | 96:4 1997.04[民86.04] |
頁次 | 頁247-252 |
分類號 | 417.281 |
關鍵詞 | 子宮頸良性病變; 子宮頸惡性病變; 螢光光譜; Fluorescence spectroscopy; Cervical neoplasia; |
語文 | 英文(English) |
英文摘要 | In Taiwan, cervical cancer is the leading malignancy among women. For the early detection of cervical neoplasia, ligh-induced fluorescence spectroscopy was conducted exvivo to assess the ability of this technique to differentiate cervical neoplastic tissue (20 samples) from normal or inflammatory cervical tissue (37 samples) at an excitation wavelength of 280 nm. The principal fluorescent peaks occurred within ± 5 nm of 330 nm and 470 nm emission. At 330 nm emission, the spectrum of the normal or inflammatory tissue was significantly stronger than that of the neoplastic tissue after area normalization. However, at 470 nm emission, the spectrum of the normal or inflammatory tissue was significantly weaker than that of the neoplastic tissue. A diagnostic algorithm based on the ratio of relative intensities of 330 nm to 470 nm emission within the ± 5 nm peak area of each sample was calculated and paired. The ratios showed that histologically neoplastic lesions could be distinguished from inflammatory samples using a 280-nm-excitation wavelength with a sensitivity, specificity and positive predictive value of 94%, 82% and 73%, respectively. The average ratio of malignant or dysplastic cervical samples was significantly greater than that of the inflammatory samples (p<0.001). Our ex vivo study indicated that light-induced fluorescence spectroscopy may be useful in differentiating malignant or premalignant from normal or inflammatory cervical tissue. |
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