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頁籤選單縮合
題名 | Identification of Classic and Complex t(15;17) and/or RARα/PML Gene Fusion in APL by Cytogenetic and Dual Color-Fish Techniques=細胞染色體及雙色螢光原位雜合法鑑定--急性白血病內異型及複雜型染色體15至17之移位和RARα/PML基因接合 |
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作者 | Acar,Hasan; Dundar,Munis; Stewart,Janet; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷期 | 21:2 1997.04[民86.04] |
頁次 | 頁54-60 |
分類號 | 415.375 |
關鍵詞 | 細胞染色體; 雙色螢光原位雜合法; 急性白血病; APl; t(15;17)(q22;q12-21); RARα/PML; Fluorescence in situ hybridization; |
語文 | 英文(English) |
中文摘要 | 急性前白血球白血病(APL)具有特別之染色體變化:由染色體15q22移位到染色 體 17 之 q12,使得 PML 基因接合到染色體 17 上的 RAR α基因。本研究利用傳統之核型 分析尋找染色體 15 至 17 之移位,再由雙色螢光原位雜交法在分裂間期( interphase ) 證實 PML 及 RAR α基因之接合。 兩種方法得以在 APL 病人的系列骨髓或周邊血球檢體內 發現病變細胞,結果發現第二種分子雜交技術的確有助於傳統染色體分析。 |
英文摘要 | Acute promyelocytic leukemia (APL) is a malignant condition characterized by t(15;17)(q22;q12), which fuses the PML gene on chromosome 15 to the retinoic acid receptor alpha (RAR α ) gene on chromosome 17. In this study, t(15;17) was identified cytogenetically by using the conventional cytogenetic technique, and its molecular counterpart RAR α /PML fusion on chromosome 17 on interphase nuclei was further confirmed by means of dual color- (DC-) fluorescence in situ hybridization (FISH) on serial bone marrow (BM) and peripheral blood (PB) samples from APL patients at different stages of the disease. Overall, our findings indicate that interphase DC-FISH analysis can be a useful technique as an adjunct to conventional cytogenetic investigation for detecting the presence of RAR α /PML fusion in APL. |
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