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題名 | Alleviation of Hemorrhagic Shock-Induced Hepatic Adenosine Triphosphate Depletion by Enterectomy in Rats=腸子切除對出血性休克引致老鼠肝內三燐酸腺苷酸含量下降之緩解作用 |
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作 者 | 張財旺; 林炳文; 張敏政; | 書刊名 | 中華民國外科醫學會雜誌 |
卷期 | 30:2 民86.03-04 |
頁次 | 頁86-91 |
分類號 | 416.123 |
關鍵詞 | 腸子切除; 出血性休克; 老鼠; 肝; 三燐酸腺苷酸; Gut; Hepatic; ATP; Hemorrhagic shock; |
語文 | 英文(English) |
中文摘要 | 本研究是以Wiggers休克模式來研究大小腸切除對出血性休克時肝臟內三燐酸腺�� 酸( ATP )含量的影響。在放血產生休克前,實驗組之老鼠先接受全部大小腸切除。 於二 小時的休克期閒,實驗組及對照組動物平均血壓都維持在 30-35mmHg 之間。休克期結束後, 放出的血再經靜脈導管注射回去動物的血液中。接著,再經三小時的觀察以記錄血壓及存活 率後。 隨後,取出實驗動物的肝臟組織以測量其 ATP 的含量。結果,腸未切除老鼠之休克 死亡率為 41 %( 5/12 ),而腸切除老鼠之休克死亡率為 0 %( 0/13 ), 二者比較有 顯著差異( p<0.05, Fisher's exact test )。 同時使用 luminometric 法測定肝內 ATP 含量時發現肝內 ATP,不論是實驗組或對照組,都會因出血性休克而有明顯下降,然而腸未 切除之老鼠在休克結束三小時後, 其肝內 ATP 之含量( 367 ± 95 nmol/gm, mean ± SEM, n=7 )遠低於腸切除老鼠的數值( 870 ± 100 nmol/gm, mean ± SEM, n=13; p<0.05 )。這項發現顯示大小腸切除可能會緩和出血性休克所引發的肝內 ATP 之下降,並 增加老鼠休克後之存活率。 同時,也暗示腸子在出血休克致肝內 ATP 降低及引起不可逆休 克過程中扮有重要角色。 |
英文摘要 | In this study the Wiggers shock model was used to investigate the effect of the intestines on hepatic adenosine triphosphate (ATP) levels after hemorrhagic shock. Rats were subjected to laparotomy for the removal of the entire small and large intestines (experimental group) and sham operation (control group) prior to bloodshedding. During the period of shock, the animals were maintained at 30-35 mmHg arterial pressure for two hours. After reinfusion of the shed blood, survival data were recorded for three hours and liver tissues were sampled from the survivors. The lethality rates were 41 ﹪ (5/12) and 0 ﹪ (0/13) for the sham-enterectomized and enterectomized groups, respectively (P<0.05). Measurement of hepatic ATP by the luminometric method showed that hepatic ATP contents were significantly reduced in both the experimental and control groups after shock (p's < 0.05). However, hepatic ATP depletion of greater magnitude occurred in the control group; significantly lower amounts of ATP were demonstrated in the liver tissues of the sham-enterectomized group (367 ± 95 nmol/gm, mean ± SEM, n=7) than in that of the enterectomized group (870 ± 100 nmol/gm, mean ± SEM, 1=13) at 5 hours postshock (p< 0.05). Conclusions: These experimental findings show that in the absence of the intestines, hemorrhagic shock is associated with both an improved survival outcome and higher hepatic ATP levels in rats, suggesting the importance of intestinal participation in process leading to hepatic ATP depletion and irreversibility in shock. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。