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題名 | Intravenous Infusion of Low Dose Propofol for Conscious Sedation in Cesarean Section before Spinal Anesthesia=剖腹產脊髓麻醉前以低劑量Propofol靜脈連續注射作清醒鎮靜 |
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作者 | 鄭雅蓉; 王永彬; 范守仁; 劉健強; | 書刊名 | 麻醉學雜誌 |
卷期 | 35:2 1997.06[民86.06] |
頁次 | 頁79-84 |
分類號 | 417.372 |
關鍵詞 | 產科麻醉; 生產; 剖腹產; 鎮靜劑; 非巴比妥鹽; Obstetric anesthesia; Delivery; cesarean section; Nonbarbiturate sedatives; Propofol; |
語文 | 英文(English) |
英文摘要 | 背景:清醒鎮靜(conscious sedation)對解除剖腹產病人之焦慮、呼吸道之維護 和保存生產經驗,較重度鎮靜為適當。 依過去之文獻報告顯示,propofol 靜脈灌注可提供 區域麻醉病人良好之鎮靜。雖然 propofol 曾安全地用於剖腹產之全身麻醉誘導,但以低劑 量持續靜脈灌注施行麻醉前及麻醉中鎮靜,對母親及胎兒之影響則尚待評估。方法:本實驗 以兩組剖腹產之病人, 一組在脊髓麻醉前接受低劑量 propofol 灌注 (先靜脈注射 0.3mg/kg,然後滴注 3 mg/kg/h), 另一組則未接受任何藥物,除比較母親接受麻醉後血行 動力學之變化和鎮靜效果及生產經驗之維持以外, 並比較胎兒之 APGAR 分數及臍血血氧等 分析。母親及胎兒在娩出時之 propofol 濃度也以氣體色層分析法測量,以了解持續灌注之 胎盤穿透。 結果:分娩前平均灌注時間為 32.6 ± 7.7 分鐘。此方法可提供滿意的鎮靜效 果,病人較平靜、合作並可保持言語反應及呼吸道暢通。兩組病人麻醉後之變化和嬰兒之評 估並無差別。 娩出時母親及胎兒之 propofol 血漿濃度分別為 0.86 ± 0.29 和 0.33 ± 0.11 μ g/ml,並且和灌注時間長短無關。結論:低劑量 propofol 靜脈灌注用於剖腹產麻 醉前之清醒鎮靜,對母親和胎兒均能維持相當之安全度,而灌注時間並不增加胎兒血漿之藥 物濃度。 tions in the mean time of delivery in maternal vein and umbilical vein were 0.86 ± 0.29 and 0.33 ± 0.11 μ g/ml, respectively. Umbilical venous concentration neither correlated with infusion time nor exceeded the maternal venous concentration. The 1-min and 5-min Apgar scores as well as umbilical venous blood as analyses did not differ significantly between two groups. Conclusions: Conscious sedation by low dose propofol infusion is safe for both mother and fetus in spite of longer infusion time. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。