頁籤選單縮合
題 名 | 中醫傳統方劑對於大鼠實驗性心律不整之研究=The Studies of Chinese Traditional Prescriptions on the Experimental Arrhythmia in Rats |
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作 者 | 蔡輝彥; | 書刊名 | 中醫藥年報 |
卷 期 | 15:1 1997.05[民86.05] |
頁 次 | 頁431-487 |
分類號 | 413.4 |
關鍵詞 | 中醫傳統方劑; 實驗性心律不整; Chinese traditional prescriptions; Experimental arrhythmia; |
語 文 | 中文(Chinese) |
中文摘要 | 心律不整在傳統中國醫學中屬怔忡、驚悸之範疇,歷代醫家對於此證候之病因、 病機、治法方藥等有諸多論述,強調辯證分型,依證型靈活運用處方,本研究乃選擇臨床常 用之四種辯證分型法則,分別選出各型之代表性方劑: 心血兩虛型 (歸脾湯 )、氣陰兩虛型 (炙甘草湯 )、脈絡瘀阻型 (血府逐瘀湯方 )、陰虛火肚型 (天王補心丹 ), 利用動物實驗 之模式, 以不同藥物誘發大鼠實驗性心律不整,觀察這四種方劑 (濃度分別為 0.5 g/kg、 l.O g/kg、 2.O g/kg 靜脈注射給藥 ) 對於 Picrotoxin、 Aconitine、 Ouabain、 Epinepherine 等四種藥物誘發心律不整之預防效果。結果顯示: 1. 歸脾湯與天王補心丹對 於 Picrotoxin 所誘發 (3.5 mg/kg,iv) 之心律不整的效果最佳。 對誘發之潛伏期有延長 作用, 對心律不整作用時間則有縮短之作用, 甚至有完全對抗之效果。 顯示此二方劑對 Picrotoxin 所致中樞興奮之心律不整有抑制作用。 2. 各方劑之實驗組對於 Aconitine 所 誘發 (35 ug/kg,iv),心律不整之預防作用,與對照組並無顯著差異。3. 炙甘草湯與與血 府逐瘀湯對於 Ouabain 誘發 (0.5 mg/min,iv infusion) 心律不整之預防作用。能明顯提 高心室早期收縮閾值及大鼠致死劑量。 顯示此二方劑對 Ouabain 所致之心律不整有對抗作 用。 4 .炙寸草湯對於 Epinephrine (5 ug/min, iv infusion, 每隔十分鐘再加 lO ug/min) 所誘發之心律不整有提高心室早期收縮閾值之作用。天王補心丹與中劑量之炙甘草 湯有提高致死劑量之作用; 而血府逐瘀湯之致死劑量平均值亦高於對照組,但未達統計學意 義。5 .對血壓之影響方面,炙甘草湯與天王補心丹在低 (0.5 g/kg)、中 (l.0 g/ kg) 劑 量有升壓作用,在高 (2.0 g/kg) 劑量則有降壓作用,顯現出雙向調節之功能; 歸脾湯與血 府逐瘀療湯於高劑量亦有降壓作用。 6. 對心率方面,各方劑皆有使心跳減緩之作用。由以 上結果顯示,中醫傳統方藥對於心律不整之治療應有其獨特的效果,而且不同的方劑對於同 一症狀之治療效果顯現不同的結果。可見傳統中醫之治療,需配合臨床之辨證論治,隨證用 藥,才可收到更好的療效。至於其作用機轉有待更進一步的探討。 |
英文摘要 | In traditional Chinese medical science, arrhythmia belongs to the category of severe palpitation (zeng chong, 怔忡 ), frighten palpitation (jing jih, 警悸 ). Chinese medical physicians through the ages had set up many comments about its cause, mechanisms, therapeutic principles and prescriptions, and emphasized differential diagnosis, and employed prescriptions according to the type of diagnosis. According to the principles of differential diagnosis which were frequently used in clinical, four representative prescriptions were chosed in this study: for insufficiency of heart-blood (心血兩虛 ): Guei- Pyi-Tang (歸脾湯, EQ); for deficiency of both vital energy and yin( 氣陰兩虛 ): Zhi-Gan- Tsao-Tang (炙甘草湯, GC); for blood stasis of channel and meridian(8( 脈絡瘀阻 ): Shiee-Fu-Jwu-Iu-Tang (血府逐瘀湯, SF); for insufficiency of yin leads to hyperactivity of fire (陰虛火旺 ): Tian-Wang-Buu-Shin-Dan (天王補心丹, TW), respectively. In order to induce experimental arrhythmia in rats, four different inducers (picrotoxin, aconitine, ouabain and epinephrine ) were used. The effects of these four prescriptions (0.5 g/kg, 1.0 g/kg and 2.0 g/kg) on the prevention of arrhythmia induced by each inducer were observed. The following results were obtained: 1. EQ and TW were the most effective prescriptions on the picrotoxin-induced arrhythmia: They prolonged the induced latency and shortened the duration of arrhythmia even entirely antagonized. 2. All prescriptions have no significant differences in the prevention of aconitine-induced (35 μ g/kg, iv) arrhythmia. 3. GC and SF could prevent the ouabain-induced arrhythmia and signifcantly increase the threshold of premature ventricular constraction (PVC) and the lethal dose of rats. 4. GC could prevent the arrhythmia and increased the threshold of PVC induced by epinephrine. TW and GC (1.0 g/kg) increase the lethal dose induced by epinephrine. And the lethal dose of SF was higher than the control group but no significant in statistics. 5. GC and TW were dual modulation in rat arterial blood pressure. They produced hypertensive effect in low (0.5 g/kg ) and median (1.0 g/kg ) doses, but hypotensive effect in high (2.0 g/kg ) dose. EQ and SF showed makedly hypotensive effect. And all prescriptions could attenuate the heart rate. The above results showed that the therapy of traditional chinese medical prescriptions on arrhythmia has unique effect. The therapeutic effect in different prescriptions on the same sign showed different results. Therefore, the therapy of traditional chinese medical science had to be based on the clinical differential diagnosis. the uses of medicines usually accorded the symptoms and signs. However, the mechanisms of all prescriptions need to be further investigated. |
本系統中英文摘要資訊取自各篇刊載內容。