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題 名 | 中醫治療單純兊疹第二型感染之研究=Anti-Herpes Simplex Virus TypeⅡ Chinese Herbal |
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作 者 | 鍾楚紅; | 書刊名 | 中醫藥年報 |
卷 期 | 15:1 1997.05[民86.05] |
頁 次 | 頁355-399 |
分類號 | 413.412 |
關鍵詞 | 抗病毒; 單純疱疹病毒第二型; Antivirus; Herpes simplex virus type 2; |
語 文 | 中文(Chinese) |
中文摘要 | 挑選相當於西醫單純庖疹之中醫治療"熱瘡""火瘡"有效之22種單味中藥與處方之 水層中藥抽取物進行抗單純庖疹 HVS-2 病毒試驗。 經由細胞毒性試驗得對 Vero 細胞無毒 性 (即細胞存活率最接近 90% 者 ) 之水層抽取物之最高濃度 (即最低細胞毒殺濃度 ),海 藻為 1Omg/ml,蒲公英為 1 mg/ml,敗醬草及芙蓉菊為 0.00l mg/ml 外, 其餘 18 種均為 0.l mg/ml。 本研究是使用細胞病變法來作抗 II 型單純庖疹病毒篩選,結果顯示 22 種中 藥材之水層抽取物分別 (1) 6 種 (27.3%) 於同時給藥途徑有效, (2) 4 種 (18.2%) 於治 療給藥有效,(3) 8 種 (36.4%) 於預防給藥途徑有效,(4) 6 種 (27.3%) 於管外給藥途徑 有效。但四種給藥途徑之抗病毒效果程度並不一致。本研究結果顯示無四種給藥途徑皆有效 之中藥材水層抽取物。 |
英文摘要 | Water extract of 22 herbal drugs was selected for antiherpes simplex type 2 virus study. The viruses were inoculated into the Africa green monkey cell line. Vero' which was cultured in our laboratory. The tests for relative minimum concentration of cytotoxicity (MCC) of herbal drug preparation to the Vero cells for Sargassum fusiforme (Harv.) Setch. was 10 mg Patrinia scabiosaefolia Fisch and Crossotephium chinense(L ) Mak. ex Cham et Schltr. Were 0.001 mg/ml. The relative MCC tested for the other 18 herbal drugs studied were 0.1 mg/ml. Four types of drug administration were tested in this study, namely simulteneous administration, therapeutic administration preventive administration' and premix in vitro administ- ration. Our results showed that 6 of the 22 herbal drugs (27.3%) were effective in simulteneous administration; 4 of the 22 herbal drugs (18.2%) were effective in therapeutic administration; 8 of the 22 herbal drugs (36.4 %) were effective in preventive administration; 6 of the 22 herbal drugs (27.3%) were effective in premix in vitro administration. None was effective in all four types of drug administration. |
本系統中英文摘要資訊取自各篇刊載內容。