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題名 | Acyclovir之神經精神性副作用--病例報告=Neurologic and Psychiatric Side-Effects of Acyclovir--A Case Report |
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作者姓名(中文) | 宋奉宜; 連慧敏; 周國璋; 吳啟欽; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 15:2 1997.06[民86.06] |
頁次 | 頁141-145 |
分類號 | 418.285 |
關鍵詞 | 神經精神性副作用; Acyclovir neurotoxicity; AN; Herpes zoster-associated encephalitis; HZAE; Hemodialysis; Renal failure; |
語文 | 中文(Chinese) |
中文摘要 | 關於acyclovir用於帶狀泡疹之治療成效,已有許多文章詳述。多年以來該藥物已經成為治療帶狀泡疹之首選抗病毒製劑。然而也有報告顯示acyclovir引致神經方面的不良影響。其中又以靜脈注射給藥之病例為多。本文報告一位八十四歲失聰男性,有三年到四年之隔日洗腎病史。經十二次口服600毫克(共7200毫克)劑量治療右額部帶狀泡疹後發生神經精神症狀。相關實驗室數據及神經學證據排除帶狀泡疹性腦炎或代謝異常性腦病變後,診斷為acyclovir之藥物精神毒性。經二次血液透析後,無合併其它特殊治療,症狀消失,神智恢復。 |
英文摘要 | The efficacy of acyclovir in the treatment of herpes zoster has been well documented and it remains the primary antiviral therapeutic choice for herpes zoster for years. The adverse effects, including neurologic and psychiatric signs, attributed to acyclovir therapy are also reported. Most of these effects are seen during intravenous therapy. We herein report a case of herpes zoster in an 84-year-old male, deaf, hemodialytic patient. Oral acyclovir 600 mg Q4hr (total dosage 7200 mg) was given. Conscious disturbance developed after the 12th dose. Herpes zoster induced encephlitis or metabolic encephalopathy was not likely after laboratory and neurologic examinations, and acyclovir neurotoxicity was impressed. Mental status recovered after two sessions of hemodialysis without any other specific treatment. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。