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頁籤選單縮合
題名 | Heterogeneous Distribution of Myocardial Magnesium in Rat Myocardial Infarction Model=成年鼠心肌梗塞模式中心肌內鎂離子之分佈差異 |
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作者 | 王宗倫; 張珩; 曾淵如; | 書刊名 | Acta Cardiologica Sinica |
卷期 | 13:1 民86.01-03 |
頁次 | 頁19-26 |
分類號 | 415.3161 |
關鍵詞 | 鎂離子; 心肌梗塞; Wistar白鼠; Magnesium; Myocardial infarction; Wistar rats; |
語文 | 英文(English) |
中文摘要 | 目的:過去研究報告顯示鎂離子對於心肌梗塞患者有保護心臟效果,但機轉未明。本實驗即以成年白鼠心肌梗塞模型,研究心肌細胞鎂離子分佈情形。 方法:吾人以20隻成年白鼠心肌梗塞模型,來定量心肌組織鎂離子含量變化。除控制組4隻白鼠外,每隻動物先接受左冠狀動脈結紮30分鐘後釋開。其後再分別予以靜脈注射不同劑量的硫酸鎂,即O(第一組4隻白鼠),8(第二組4隻白鼠),15(第三組4隻白鼠)及30 mmol/Kg(第四組4隻白鼠)。心肌梗塞區域以Triphenyl tetrazolium chloride(TTC)染色法決定。血清、心肌梗塞區域心肌,及非心肌梗塞區域心肌用以定量鎂離子含量。 結果:在第一至四組中,心肌梗塞區域心肌鎂離子含量遠比非心肌梗塞區域心肌鎂離子含量低。而控制組的心肌鎂脽子含量不因取樣位置而有差異。血清鎂離子濃度與心肌梗塞區域心肌鎂離子含量並無任何對應關係(r=0.22,NS),而血清鎂離子濃度與非心肌梗塞區域心肌鎂離子含量則有顯著正相關(r=0.81,P < 0.0001)。此外,心肌梗塞後早期重灌流期,應只有間接而非直接對梗塞心肌細胞保護作用。 |
英文摘要 | Purpose. Magnesium has been proved to have protective effects for those with acute myocardial infarction although the mechanism remains to be elucidated. This study was designed to investigate the distribution of myocardial magnesium in an animal myocardial infarction model. Methods. Myocardial magnesium was quantified in 20 adult male Wistar rats of myocardial infarction model. After ligations of left coronary artery for 30 minutes (except in 4 animals as control group), magnesium was administered intravenously with doses of o (Group 1; n=4), 8(group 2;n=4), 15(group 3; n=4) and 30 mmol/Kg body weight (Group 4; n=4) after release of ligation. The infarct area was determined by stain of triphenyl tetrazolium chloride (TTC). Tissue samplings from infarct (TTC stain positive area) and non-infarct sites (TTC stain negative area) were taken for measurement of tissue magnesium. Result. The magnesium levels of infarcted myocardium were significantly lower than those of non-infarcted areas in group 1 to 4, whereas there were no differences in tissue magnesium levels from different sampling sites in control group. Significant correlation was found between serum magnesium and tissue magnesium of infarcted myocardium (r=0.22, NS). However, there was a significantly positive association between serum magnesium and tissue magnesium of non-infarcted myocardium (r=0.81, p<0.0001). In addition, iffarct size kept nearly constant even under the increase of serum magnesium or non-infarcted myocardium magnesium. Conclusions. Magnesium may provide only an indirect, instead of direct, effect on infarcted myocardium in the early phase of reperfusion. |
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