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題 名 | Wistar大鼠的Peyer's Patch中腸神經分佈的研究模型之建立=Establishing a Model of Enteric Nerve Distribution to the Peyer's Patch in Wistar Rats |
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作 者 | 林天仁; 張其真; 邱紹智; 洪昭竹; 吳銘芳; | 書刊名 | 中國醫藥雜誌 |
卷 期 | 2:1 1997.03[民86.03] |
頁 次 | 頁27-32 |
分類號 | 415.149 |
關鍵詞 | 黏膜免疫系統; 腸系神經系統; Mucosal immune system; Enteric nervous system; Peyer's patch; |
語 文 | 中文(Chinese) |
中文摘要 | 有關黏膜免疫系統(mucosal immune system)與腸神經系統(enteric nervous system)之間交互影響作用的機制,目前不是很了解; 而且在腸系神經系統支配Peyer's patch的功能作用方面,尚處於模糊未明的謎題之中。吾人利用Wistar大鼠為研究模式來探討此一機制而得知位於Peyer's patch的腸系神經由三組俱神經節的神經纖維所組成,分別為:腸肌叢(myenteric plexus)、外黏膜下叢 (external submucosal plexus)、內黏膜下叢 (internal submucosal plexus),且經由S-100蛋白的表現顯示在 Peyer's patch的神經節是起源於神經脊(neural crest);此外在成熟Wistar大鼠的腸系神經系統中,支持細胞為神經膠質所組成, 而非許旺細胞 (Schwann cell)。 在我們的實驗中發現, 對Neurofilament蛋白之免疫組織化學染色呈正反應的神經纖維分佈的節結間區(interfollicular area),從外黏膜下叢神經節到內黏膜下叢神經節。這些實驗觀察的結果證明了在大鼠的Peyer's patches和腸神經系統之間有一定程度相互聯絡及影響的關係。 |
英文摘要 | The intercommunication between the mucosal immune system and the enteric nervous system (ENS) is not fully understood. In addition, the enteric nervous system's innervation to the Peyre's patch (PP) remains puzzling and obscure. The enteric nerve supplying the Peyer's patch consists of three groups of ganglionated nerve fibres: the myenteric plexus, the external submucosal plexus and the internal submucosal plexus. The expression of S-100 protein on the ganglion of the PP revealed their neural-crest derived origins. Besides, the ENS is supported by glia instead of Schwann cells in the adult Wistar rat gut. Neurofilament protein immunhistochemical stain positive nerve fibres were reported to be found along the inter-follicular area from the ganglia of the external submucosal plexus to the ganglia of the internal submucosal plexus between the follicle. These observations show that the ENS nerve cells have a certain degree of intercommunication with the rat PPs. |
本系統中英文摘要資訊取自各篇刊載內容。