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題名 | A Physical Model for the Description of Dissolution Behavior of Cholesterol Monohydrate Pellet in Aqueous Bile Salt Solutions=一種物理模式來描述膽固醇單體顆粒在膽汁酸鹽溶液中的溶解現象 |
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作者 | 劉振倫; | 書刊名 | 界面科學會誌 |
卷期 | 19:3 1996.09[民85.09] |
頁次 | 頁145-154 |
分類號 | 361.8 |
關鍵詞 | 膽固醇單體; 反應控制; 擴散控制; Cholesterol monohydrate; Reaction-controlled; Diffusion-controlled; |
語文 | 英文(English) |
中文摘要 | 一種物理模式被用來描述膽固醇單體顆粒在不同種膽汁酸鹽及氯化鈉濃度溶液中的溶解現象,對於膽汁酸鹽tauroursodeoxycholate (TUDC),taurocholate (TC),及taurochenodeoxycholate (TCDC)的個別溶液中,當氯化鈉的濃度較高時,達到穩定所需的時間可被忽略,同時在交界面的障礙會減少很多,但擴散層僅少量的減少;在膽固醇單體顆粒中,描述膽固醇濃度變化的液相孔長度,會隨著氯化鈉的濃度增加而減少,而在交界面的膽固醇濃度隨著增加,顯示與交界面的障礙會減少相符合。更進一步的評估證實,在尚未達到穩定時,膽固醇單體的平均溶解速率與達到穩定時的溶解速率相接近,此分析提供出,當溶解速率由反應控制變為擴散控制時,關於擴散層及在膽固醇單體顆粒內的膽固醇濃度變化情形。 |
英文摘要 | A physical model was introduced to describe cholesterol (Ch) monohydrate (ChM) dissolution behavior in different concentrations of bile salt and sodium chloride (NaCl) solutions. For tauroursodeoxycholate (TUDC), taurocholate (TC), and taurochenodeoxycholate (TCDC) solutions with high NaCl concentrations, the time required to reach a steady state was negligible. The diffusion layer decreased slightly with increasing NaCl concentrations when the interfacial barrier decreased dramatically. The depth of aqueous pores within the ChM pellet for the change of Ch concentration decreased while the Ch concentration at the interface increased with increasing NaCl concentrations, indicating a decrease of the interfacial barrier. Further estimation showed that the average dissolution rate of ChM before a steady state was close to the dissolution rate at a steady state. These results provide more information regarding the dissolution changes of the diffusion layer and Ch concentration profile within the ChM pellet when a reaction-controlled case is shifted to a diffusion-controlled case. |
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