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題 名 | Pretransplant Mixed Lymphocyte Reactivity (MLR) Fails to Predict the Outcome of Islet Allotransplantation in Congenic Mice=以混合淋巴球反應試驗預測胰島細胞共基因鼷鼠移植結果 |
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作 者 | 趙世晃; | 書刊名 | 中華民國外科醫學會雜誌 |
卷 期 | 29:4 民85.07-08 |
頁 次 | 頁297-305 |
分類號 | 437.245 |
關鍵詞 | 混合淋巴球反應; 胰島細胞; 共基因; 鼷鼠移植; Mixed lymphocyte reactivity; MLR; Inbred; Pancreatic islet; Allogenic; Transplantation; |
語 文 | 英文(English) |
中文摘要 | 使用不同共基因(congenic.鍵鼠進行異種胰島移植會有不同的移植結 果。我們嘗試了解這種差別結果是否與鍵鼠先天免疫狀態有關。混合淋巴球反應 試驗(mixedlymphocytereaction,MLR)是移植前預測植體是否引發宿主強烈排斥反 應的標準措施,本研究目的在利用MT@R來調查同籠純種鍵鼠移植前之免疫狀 態,並探討此MLR之高低是否與移植結果差異有相關性。材料與方法:同批反應 者(responder.鍵鼠BioBR(H.2。)(n:30)進行脾臟半切除(hemisplenectomy.並分離得 脾細胞,與經放射線處理之C。,BL/6(H.2。)或DBA/2J(H.2。)體鼠脾細胞混 培養,此胰島移植前之MLR呈現相當之差異範圍:刺激指數(stimulation index,SI)從 3.0到12.9。同批B10BR鼷鼠在接受異種胰島移植後,13隻發生排斥,3隻發生原發 無功能(primary nonfunction,PNF),6隻呈慢性容受。另3隻死亡,5隻因控制因素不 良除外。不過移植前鼷鼠之MLR高低並不平行於移植結果,所以純種鼷鼠之移植 結果差異性無法以移植前鼷鼠之免疫狀態來預測。僅管同籠之鼷鼠MLR呈現差異 性,不過此差異性在胰島移植前後呈現大輻變動,是以不足以預測移植結果。 |
英文摘要 | Congenic mice are known to have different responses to islet allo-transplantation. We studied whether the pretransplant primary mixed lymphocyte reactivities (MLRs) would predict outcome. Splenocytes (responders)from 30 hemisplenectomized BIOBR (H2-k) recipients were cultured withirradiated stimulators from C57BL/6 (H2-b) or DBA/2J (H2-d) donors beforeislets allo-transplantation. The values of pretransplant MLRs showed adiversity within one order of magnitude (stimulation indexes: S.I. = 3.0-12.9).However, there was no correlation between MLR responses and outcome oftransplant in terms of graft rejection (n=13), acceptance (n=6), or primarynonfunction (n=3). The remaining mice were excluded because unexpecteddeath (n=3) and poor technical control (n=5). The inability of pretransplant MLRs to predict the allograft survival can be interpreted by the limiteddiversity of MLRs among littermates of inbred mice, and by the unsteadydynamics of MLRs following pretransplant manipulations. |
本系統中英文摘要資訊取自各篇刊載內容。