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題名 | 以p53、PCNA、C-erbB-2等單元抗體之免疫組織化學染色對眼瞼皮脂腺癌預後評估=Prediction of Prognosis of Sebaceous Gland Carcinomas in Eyelids by Immunohistochemical Staining with p53, C-erb B-2 and PCNA Monoclonal Antibodies |
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作者姓名(中文) | 王一中; 蔡建誠; 沈詩詠; 曾效參; 高啟祥; 侯平康; | 書刊名 | 中華民國眼科醫學會雜誌 |
卷期 | 35:2 1996.06[民85.06] |
頁次 | 頁7-13 |
分類號 | 416.752 |
關鍵詞 | 單元抗體; 免疫組織; 化學; 染色; 眼瞼皮脂腺癌; Sebaceous gland carcinoma; p53 tumor suppressor gene; C-erbB-2 oncogene; Proliferating cell nuclear antigen; |
語文 | 中文(Chinese) |
中文摘要 | 眼瞼皮脂腺癌是一種好發於東方人、老年人的稀有眼險惡性腫瘤。在台 灣其發生率僅次於眼瞼基底細胞癌佔所有眼瞼腫瘤的第二位。通常是以眼瞼瞼板 部緩慢發展之無痛性,黃白色腫瘤。在眼瞼緣則容易導致眼睫毛脫落,甚至引起 皮膚或結膜之糜爛和潰瘍。在臨床上常與復發性霰粒腫混淆,所以會造成診斷的 延遲,而造成治療上的困擾和失敗。其散佈方式一是局部的侵蝕擴張;另一為經 由淋巴腺之轉移到耳前或耳下淋巴腺,但也可至下顎或甚至整個頸部淋巴腺。本 研究材料是以台大醫院從民國六十九年到八十三年間經病理診斷為眼瞼皮脂腺 癌病人之手術病理標本,以p53、c-erbB-2)和PCNA單元抗體之免疫組織化學染色 來預側其預後,並分析其臨床資料來尋找其和預後有關因素。我們發現病人的預 後和p53抗原、C-erbB-2和PCNA指數的大小無明顯的相關,但是和病灶的表現有 較大的相關性,例如病灶是局部表現或散佈性表現,是否有轉移,治療方式,和 發病年紀較有關聯。所以在評估此類病人時,詳細的臨床檢查和影像分析檢查是 相當重要的,而這些標記對眼瞼皮脂癌的價值可能需要再詳細的評估。 |
英文摘要 | Sebaceous gland carcinoma is a rare eyelidtumor. This tumor deveolpes late in life with the mostvulnerability between the age of 40 and 75 years.Orientals may be affected disproportionately. Italways presents slow-growing, yellowish elevationon the tarsus of the eyelid and is often mistaken for arecurrent chalazion. Pagetoid spread of the neoplasticcells in the overlying epithelium is an importantfeatures for differentiating from basal cell carcinomas.In this study we use immunohistochemical stainingwith monoclonal antibodies of p53, c-erbB-2, and proliferating cellular nuclear antigen (PCNA) topredict the prognosis of sebaceous gland carcinomain eleven patients. There is no correlation betweenthe staining of these antibodies in pathologicalspecimens and the prognosis of sebaceous glandcarcinoma. The risk factors of this tumor are relatedto the growth pattern of tumor, metastasis to regionallymph onde, age of patients, and treatment. Theclincal assessment of tumor growth is more importantthan immunohistochemical staining by theseantibodies. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。