頁籤選單縮合
題名 | 膳食中之抗致突變物及其作用機制=Review on the Dietary Antimutagens and Their Mechanisms of Action |
---|---|
作者 | 陳惠英; 顏國欽; Chen, Hui-yin; Yen, Gow-chin; |
期刊 | 中華民國營養學會雜誌 |
出版日期 | 19960800 |
卷期 | 21:3 1996.08[民85.08] |
頁次 | 頁323-338 |
分類號 | 411.3 |
語文 | chi |
關鍵詞 | 致突變物; 抗致突變物; 作用機制; 去致突變物; 生物抗致突變物; Mutagens; Antimutagens; Mechanisms of action; Desmutagens; Bioantimutagens; |
中文摘要 | 近年來的流行病學調查指出人類癌症的發生與膳食攝取有相當重要的關聯,而許多研究也自鹽漬魚肉、發酵蔬菜、燒烤肉類、黴菌感染之食物等分離鑑定出多種致突變成分。雖然膳食中含有致突變物質,然而膳食中也含有許多可以提供保護作用之抗致突變物。流行病學實料顯示,經常攝食某些食品,特別是水果與黃、綠色蔬菜與減少某些腫瘤的危害有關。目前已被證實具有抗致突變性的膳食成分包括纖維、多盼類化合物、類黃酮化合物、類胡蘿蔔素、維生素、黃豆蛋白、微量金屬和植物化學物質等。而這些抗致突變物質之作用機制相當複雜,其可作用於致突變物及其活化物、代謝活化系統、細胞修復系統或是抑制癌細胞生長等。由於了解膳食與癌症的關連對於癌症的預防相當重要,因此在本文中將詳加敘述膳食中之抗致突變物質及其作用機制。 |
英文摘要 | Epidemiological studies have shown a relationship between several types of human cancer and particular kinds of diets. In recent years, a considerablenumber of mutagens has been isolated and identified from salted fish, fermentedvegetables, fried meat, and food contaminated by mold. However, recentresearch indicates that the human diet may also contain a number of antimutagens as well. Human epidemiological data indicate that frequent consumption ofcertain foods, especially fruits and green and yellow vegetables, is associatedwith reduced risk for some tumors. Some components in foods, such as fiber,polyphenols, flavonoids, carotenoids, vitamins, soybean protein, trace minerals,and phytochemicals, are reported to possess antimutagenic activity. The actionsof antimutagens may include multiple mechanisms, including interaction with mutagens or their metabolites, inactivation of metabolism enzyme, modulation of cellreplication, or inhibition of tumor cell growth. Therefore, the food-associatedantimutagens and their mechanisms of action are important knowledge for prevention of cancer and will be discussed in this article. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。