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題 名 | Comparisons of Long-Term Effects of Lisinopril vs Nifedipine vs Conventional Therapy in the Treatment of Mild-to-Moderate Hypertension in Patients with Chronic Obstructive Pulmonary Disease=使用血管加壓素轉換酶抑制劑、鈣離子阻斷劑及傳統療法治療慢性阻塞性肺疾合併輕度至中度高血壓病人長期療效之比較 |
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作 者 | 林廷燦; 楊允輔; 李貫棠; 姜洪霆; | 書刊名 | 中華醫學雜誌 |
卷 期 | 57:6 1996.06[民85.06] |
頁 次 | 頁392-400 |
分類號 | 415.382 |
關鍵詞 | 慢性阻塞性肺疾; 傳統療法; 高血壓; 腎素-血管加壓素系統; Chronic obstructive pulmonary disease; Conventional therapy; Hypertension; Renin-angiotensin system; |
語 文 | 英文(English) |
中文摘要 | 背景 任何高血壓病患可能罹患或伴有肺疾。高血壓對於藥物之反應 於此類病人仍屬未知數。因此有76例輕度至中等度高血壓伴有慢性阻塞性肺疾 患者納入本實驗,接受lisinopril、nifedipine或傳統治療。本篇研究旨在了解三 種抗高血壓藥物之療效以及它們對於腎素-血管加壓素系統(RAS)之作用。 方法 經過兩星期安慰劑治療,對三組病人給予不同的抗高血壓療法。一組是 給予lisinopril或加上利尿劑,另一組是給予nifedipine或加上利尿劑,第三組是 給予利尿劑及加上傳統血管擴張劑及選擇性乙型阻斷劑來治療,藥物劑量調整 至使舒張壓低於90 mmHg,而病人皆經過一年追蹤治療。 結果 經過一年之追蹤檢查,僅有66例病人完成本項實驗。所有高血壓皆可 經三種療法得到有效控制(p < 0.005)。而各組間對血壓的控制程度並無顯著的區 分。雙乘積收縮(血壓X心跳)亦呈現此種情形。lisinopril治療,雙乘積減低 最佳,但三組比較並無顯著差異。同時lisinopril組治療可壓抑RAS而傳統療法 及nifedipine組反而會活化此項系統。此外,lisinopril對新陳代謝方面有較良好 的效果。 結論 這些結果顯示此三種療法對於高血壓合併慢性阻塞性肺疾病人皆有良好 的抗血壓療效。而以預防觀點而言,lisinopril可能比傳統療法為優,但此點仍 需要長期追蹤治療方能證實。 |
英文摘要 | Background. Any hypertensive patient may be found to have associated lung disease. The response of high blood pressure to specific antihypertensive agents in this category is still unknown. Thus, a group of 76 consecutive patients with mild-to-moderate hypertension and chronic obstructive pulmonary disease (COPD) were selected to participate in a clinical antihypertensive trial to define the roles of lisinopril, nifedipine and conventional therapy, and their impact on the renin-angiotensin system (RAS). Methods. After a two-week placebo period, patients were randomly assigned to a regimen of one of three main treatment strategies: (A) lisinopril with or without diuretics; (B) nifedipine with or without diuretics; or (C) diuretics with or without conventional vasodilators (sorbitrate and hydralazine) or selective beta-blockers. The drug doses were titrated to a goal of less than 90 mmHg for maximal diastolic pressure, and the patients continued to receive therapy for at least one year. Results. After one year of follow-up, only 66 patients had completed the study. All high blood pressure was significantly reduced by the three regimens (p < 0.005), but no significant difference in blood pressure control by any individual regimen was noted. Double product also showed the similar trend. Therapy A achieved the best reduction of double product among three regimens, but statistically insignificant. Furthermore, therapy A suppressed the RAS, whereas therapies B and C might activate this system. Concomitantly, therapy A also had significant favorable effects on metabolic responses in contrast to therapy C. Therapy B revealed a neutral effect on such responses. Conclusions. These data indicated that these three main strategies could provide significant antihypertensive efficacy for blood pressure control in patients with hypertension and COPD. For preventive strategy, therapy A may provide more advantageous effects than therapy C. A long-term double-blind trial including more subjects is warranted to identify the true advantages of therapy A in reduction of major cardiovascular and respiratory events. |
本系統中英文摘要資訊取自各篇刊載內容。