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頁籤選單縮合
題名 | Early Discontinuation of Gonadotropin-Releasing Hormone Agonist in Controlled Ovarian Hyperstimulation: A Preliminary Report=在控制性卵巢高度刺激時提早停用性腺刺激素釋放素類似物:初步報告 |
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作者 | 張旭陽; 龔福財; 黃富仁; 張榮州; 蔡家璋; | 書刊名 | 長庚醫學 |
卷期 | 19:2 1996.06[民85.06] |
頁次 | 頁115-120 |
分類號 | 417.1 |
關鍵詞 | 控制性卵巢高度刺激; 性腺刺激素釋放素類似物; Controlled ovarian hyperstimulation; Gonadotropin-releasing hormone agonist; |
語文 | 英文(English) |
中文摘要 | 本研究目的在評估使用性腺刺激素釋放素類似物抑制腦下垂體後,再於卵巢刺激時繼續持續使用性腺刺激素釋放素類似物四或五天的實用性。我們提出一個新的計算方式,並且以此估算,在停用性腺刺激素釋放素類似物後可以早至六至七天,即已恢愎腦下垂體分泌性腺刺激素的功能。根據此估算接受人工生殖技術的病人,應用性腺刺激素釋放素類似物抑制腦下垂體後,接著於卵巢絘激時,只需持續使用性腺刺激素釋放素類似物四至五天,即可達到抑制腦下垂體和早發性黃體化激素高峰的目的。我們回溯35位接受提早停用性腺刺激素釋放素似物的病人,所有的病人均未出現早發性黃體化激素高峰。一位病人發生早發性黃體化現象。35位病人中有10位病人懷孕,其中一位流產。我們認為提早停用性腺刺激素釋放素是可行的。 |
英文摘要 | The purpose of this study was to evaluate the applicability of continuing daily injectable GnRHa, after pituitary desensitization, for the first 4 or 5 days of overian stimulation. We proposed a new calculation and estimated that it took as early as 6 to 7 days for pituitary and gonadotropin release to return after cessation of daily administered leuprolide acetate. A modified regimen based on this new calculation, i.e. Daily administered GnRHa continued for the first 4 or 5 days with ovarian stimulation after pituitary desensitization had been achieved was applied to patients undergoing assisted reproductive technology (ART). Thirty-five patients prospectively assigned to use this early discontinuation regimen were analyzed with respect to age, indications, duration of ovarian stimulation, dose of exogenous gonadotropin required, ovarian response and oocytes obtained, rate of fertilization, and rates of pregnancy. There was no spontaneous LH surge occurred. Premature luteinization occurred in one patient. We concluded that, after pituitary desensitization, there was no spontaneous LH surge when daily administered GnRHa continued for 4 or 5 days only with ovarian stimulation. Impacts on the ART outcome required further evaluation in a prospectively randomized study. Based on theoretical estimation, cessation of GnRHa at the beginning of ovarian stimulation might eliminate most, but not all, spontaneous LH surges. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。