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題 名 | 複方甘草合劑錠中所含嗎啡之高效液相層析定量法之研發=HPLC Analysis of Morphine in Tablet Mixture Glycyrrhizin Composite |
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作 者 | 張秀圭; 王肇; 陳家楨; 秦福壽; 李志恆; | 書刊名 | 藥物食品分析 |
卷 期 | 4:1 1996.03[民85.03] |
頁 次 | 頁41-48 |
分類號 | 418.43 |
關鍵詞 | 複方甘草合劑錠; 抽提法; HPLC法; 配對試驗; 相關係數(r); Tablet mixture glycyrrhizin composite; Morphine; Extraction method; HPLC method; Quantitative analysis; Correlation coefficient; |
語 文 | 中文(Chinese) |
英文摘要 | For the quality control of morphine content in Tablet Mixture Glycyrrhizin Composite, previously a so called <extraction> method was developed by our bureau. However, this method required acid and base treatments, repeated extraction of the sample with organic solvents, and it took about 60 working-hours. In this study, we have established an HPLC method to determine the morphine content in the product by using an Inertsil 5 ODS-2 colume (4.6x150mm), and a mobile phase consisting of 75% 2.5mM sod. 1-dodecane-sulfonate in 1% acetic acid and 25% acetonitrile. In order to compare the HPLC method with extraction method, the morphine content of 10 batches of product was quantified by both methods. The results obtained from both methods were not significantly different. The standard deviations of extraction method and HPLC method were ±1.98% and±1.94%, respectively. The correlation coefficient(r) of 10 pairs data was 0.8093, showing very significant relationship between two methods in accordance with the r-and t-tests. In addition, the HPLC method reduces the analysis time to 8 hours. These results strongly suggest that the HPLC method is more efficient than the extraction method. |
本系統中英文摘要資訊取自各篇刊載內容。