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頁籤選單縮合
題名 | A Seroepidemiological Study of Varicella-Zoster Virus in Taipei City=臺北市水痘病毒的血清流行病學研究 |
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作者 | 林逸甄; 黃立民; 李慶雲; 計大偉; 李秉穎; 張鑾英; 許峻銘; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 37:1 民85.01-02 |
頁次 | 頁11-15+69 |
分類號 | 412.729 |
關鍵詞 | 血清流行病學; 水痘病毒; 酵素免疫法; Seroepidemiology; Varicella-zoster virus; VZV; Enzyme-linked immunosorbent assay; ELISA; |
語文 | 英文(English) |
中文摘要 | 水痘是很常見的傳染病,雖然大部份的患者均病情輕微,約一週即可慢慢恢複,但仍有少數出現併發症,在高危險群的病人,甚至會出現瀰漫性疾病或死亡。目前水痘疫苗已逐漸普及,不久將來可能引進台灣,因此水痘血清流行病學研究是刻不容緩的。本計畫收集1384個不同年齡健康人的血清,利用酵素免疫法檢驗其水痘病毒抗體,得到以下結果:1)出生至三個月的嬰兒,只有24%可測得來自母親的抗體。2)陽性率在前三年緩慢增加。3)大多數水痘感染髮生在三至十歲,在此年齡陽性率快速且呈直線增加。4)約有百分之十的成年婦女及百分之二十的成年男性未曾受過感染。5)百分之八十五的懷孕婦女具有水痘抗體。由上述結果,我們建議接種水痘疫苗的年齡以介於十二個月及二十四個月之間最爲適當。將來也應篩可償還未感染成人接種水痘疫苗。 |
英文摘要 | Varicella has been considered a common and benign disease of children. However, adults tend to have severe disease and in some high risk groups, such as neonates and leukemic patients, varicella infection can be fatal. A large-scale seroepidemiological study on varicella was performed to reveal the current varicella infection status and to serve as a prevaccination survey before the possible implementation of vaccination program in Taiwan. This study included a total of 1384 individuals whose ages ranged from newborns to old adults. Enzyme-linked immunosorbent assay was adopted to determine the IgG antibodies against Varicella-Zoster virus. The results showed: (1) only 24% of infants aged birth to three months had maternal antibodies, (2) the seroprevalence increased slowly during the first 3 years after birth, (3) most infections occurred between 3 and 10 years old, (4) 10% (female) to 20% (male) of adults were still susceptible to varicella infection, and (5) 85% of pregnant women had antibodies against VZV. These data suggest that if vancella vaccination is to be done in Taiwan, the appropriate inoculation age would be between 12 and 24 months. Besides, there exists a pool of uninfected adults who potentially will develop severe illnesses once infected and should be screened and protected by vancella voccines |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。