查詢結果分析
來源資料
相關文獻
- 甲狀腺激素濃度在不同程度肝硬化病人之變化
- Pulmonary Function Changes in Cirrhotic Patients
- Recurrent Spontaneous Bacterial Empyema in Cirrhosis: A Case Report
- 肝硬化患者之細菌性感染--157位病例研究
- Isolated Fundic Varices in Liver Cirrhosis
- 肝硬化的病理治則機轉
- Effects of Intravenous Administration of Calcitriol on Serum Calcitonin Levels in Hemodialysis Patients with Secondary Hyperparathyroidism
- Can Advanced Hemostatic Parameters Detect Disseminated Intravascular Coagulation More Accurately in Patients with Cirrhosis of the Liver?
- Can the Screening Clotting Tests Predict the Complicated Hemostatic Changes in Patients with Cirrhosis of Liver?
- 壞死後肝硬化病患的營養評估
頁籤選單縮合
題 名 | 甲狀腺激素濃度在不同程度肝硬化病人之變化=Changes of Serum Thyroid Hormone Levels in Patients eith Liver Cirrhosis |
---|---|
作 者 | 楊東和; 黃文盛; 趙有誠; 許重得; 陳維廉; 郭熙文; 吳興鏞; 唐鴻舜; | 書刊名 | 醫學研究 |
卷 期 | 15:3 1994.11[民83.11] |
頁 次 | 頁171-180 |
分類號 | 415.534 |
關鍵詞 | 甲狀腺激素; 硫酸化甲狀腺激素; 肝硬化; Thyroid hormones; Sulfated thyroid hormones; Liver cirrhosis; |
語 文 | 中文(Chinese) |
中文摘要 | 由於肝臟是甲狀腺素代謝的主要週邊器官,而肝硬化又是國人常見的肝臟疾病,為了解甲狀腺激素在各種不同程度肝硬化之變化,本研究由三總肝膽研究室收集45例肝硬化病人的血清,以修飾後Child's分類,依肝硬化的嚴重程度分為Class A,B,C三組,每組各15例,並以同年齡層正常者15例為對照組。所有血清皆以放射免疫分析法進行一般甲狀腺功能檢查包括:T4,T3,FT4,TSH,TBG,及,γT3,並利用自行研發之硫酸化甲狀腺激素(T4S)及硫酸化三碘甲狀腺激素(T3S)的放射免疫分析測定,觀察不同嚴重程度肝硬化病人的傳統及替代性甲狀腺激素代謝變化。初步結果顯示三組肝硬化病人隨其嚴重程度增加,血中T4,T3及TBG呈有意義下降,其中T3值在B,C組病人更低於正常值,FT4值在A組有偏高現象(即A組與B或C組比較,p<0.05),γT3值在B,C組呈有意義增加(A組與B或C組比較,但B,C組間則無明顯差異,若以γT3/T3比值來表示時則三組間均呈有意義遞增變化。TSH值在三組間無明顯變化,在硫酸化甲狀腺素方面,可見血中T3S值在對照及三組病人間均呈有意義上升現象(正常與A,B,C三組中濃度分別為2.76±0.37,4.60±0.60,6.39±0.65和14.84±2.23 ng/dl,各組間p<0.05)。T4S值則變化不大,除C組稍高(4.21±0.05 ng/dl)外,均小於2 ng/dl,。我們的初步結論是:(1)不同嚴重性肝硬化病人可導致血中甲狀腺激素濃度的變化包括T4,T3下降及γT3上升,前者與TBG值降低可能有關,後兩者則與肝功能異常導致T3製造及γT3代謝受阻有關:(2)血中T3S值的增加,則可進一步說明肝硬化病人,肝內第一型去碘酶活性可能降低。 |
英文摘要 | Liver is a major peripheral organ of the thyroid hormone metabolism, and cirrhosis is a liver disease commonly discovered among the people. In order to understand changes of thyroid hormones in cirrhosis to various extents, this study is conducted and based on the discovery by the Hepatobiliary Research Center of Tri-Service General Hospital that collected the serum from 45 cases of cirrhotic patients and classified them into 3 groups, i.e. Class A, B and C, in line with the serious extents of their cirrhosis according the Modified Child's classification, each group comprises 15 cases and another 15 cases of normal healthy persons in the same age range are observed as the control group. The thyroid functions in general of all their serums are tested by the method of immunoradio logical assay, including such tests as T4, T3, FT4, TSH, TBG and γT3, and self-developed immunoradiologic assay and determination of both thyroxine-sulfate (T4S) and triiodothyronine sulfate (T3S) are used to observe the conventional and substitutive metabolic changes of thyroid hormones of the cirrhotic patients with different severities. The initial results indicate that the metabolic changes of all these 3-group patients suffering cirrhotic increase along with their severities, and the T4, T3, and TBG of their serum significantly decreased, wherein the patients’ T3 Value of groups B and C is lower than the normal value, the FT4 value of group A is rather high (to wit, group A in comparison with group B or C, p<0.05), andγT3 value of group B and C significantly increased (to wit, group A in comparison with group B or C, p<0.05) but there is no obvious difference between groups B and C, andγT3/T3 ratio indicates that all these 3 groups have significantly progressive changes. Since there is no obvious change of TSH value among these 3 groups in the aspect of sulfated thyroid hormones. We can tell that the T3S values of the control group and all the 3 groups A, B and C increased significantly (The serum concentration of the control group and the 3 groups A, B and C is 2.76±0.37 ng/dl, 4.60±0.60ng/dl, 6.30±0.65 ng/dl and14.84±2.23ng/dl respectively, p<0.05 among various groups). T4S value changes insignificantly and less than 2 ng/dl expect that of group C which is slightly higher (4.21±0.05 ng/dl). Our initial conclusion is so: (1) The differsnt severities of cirrhotic patients will lead to the changesof thyroid hormones concentration of their serum which include the dropping T4 and T3 and the risingγT3, the former is possibly related to the lower TBG value, and the latter is related to the abnormal liver function always leading to the resistance against the T3 synthesis and theγT3 metabolism; (2) The increasing T3S value of serum may further indicate that the type I deiodinative enzyme in the liver of cirrhotic patients may be lowered. |
本系統中英文摘要資訊取自各篇刊載內容。