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題 名 | 犬原發性生殖器外之傳染性花柳性腫瘤以Vincristine治療前後之細胞學變化 |
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作 者 | 張仕杰; 陳三多; | 書刊名 | 臺灣畜牧獸醫學會會報 |
卷 期 | 65:3 1995.09[民84.09] |
頁 次 | 頁283-295 |
分類號 | 437.66 |
關鍵詞 | 傳染性花柳性腫瘤; 細胞學; 犬; Transmissible venereal tumor; Cytology; Dog; |
語 文 | 中文(Chinese) |
中文摘要 | 一隻6歲,雄性雜種犬,約於84年元月底顯現打噴嚏及鼻?病狀,約於同時在腋窩後側發現一小團塊,隨後約在84年2月底左側鼻部上出現腫脹,而後此犬呈現間歇性鼻?症狀及腋窩後側團塊漸進性腫大現象,84年3月13日來院就診時其團塊大小已達3.5×2.8×2.52㎝3。經由細針抽吸生檢之檢查結果,診斷為犬原發性生殖器外之傳染性花柳性腫瘤。隨以後vincristine治療,每週1次;其間在第1次治療後第2天及每次治療前,皆以細針抽吸生檢,在製成抹片後,以光學顯微鏡觀察其細胞學形態與組成變化,發現傳染性花柳性腫瘤細胞有絲分裂像數目,於治療前在每100個細胞中平均為1.6±1.0個,而於vincristine投與後第2天時,在每100個細胞中平圾為14.0±3.6個,隨後呈遞減現象;而淋巴細胞於治療前每100個細胞中平均為3.5±2.5個,而在第14天時達到平均76.9±5.9個,有明顯增加之現象。且時常可見到一此個別的TVT細胞周圍有許多淋巴細胞附著;漿細胞與嗜中性球在整個治療過程中呈現緩慢的增加,但所佔比例仍然很小,經4次的治療後,腋窩後伋圍塊已完全消退,而鼻部腫脹於治療後第7天,即病畜復診時其腫脹已消退,且鼻?症狀消失。停止治療後,經3個月的追縱,得知該犬未有復發的情形,顯示癒後良好。 |
英文摘要 | Cytological studies of a six-year-old male dog of mixed breed with extragenital transmissible venereal tumor after treatment with vincristine was carried out. The dog had a history of epistaxis, sneezing and the presence of a caudal-axillary skin mass one and a half months ago before being brought to our hospital. Subsequently, swelling of the upper surface of the left nasal cavity was observed 15 dyas ago , followed by intermittent epistaxis and the caudal-axillary mass enlarged progressively. The skin mass was 3.5×2.8×2.5cm3 when it was referred to out hospital. Fine needle aspiration biopsies of the caudal-axillary skin mass and the masal swelling were performed, and a final diagnosis of primary extragenital transmissible venereal tumor was made. Vincristine (0.025mg/kg, IV) was administered once a week against the extragenital transmissible venereal tumor (TVT). The cytologic changes of 2 days after the first vincristine treatment were observed. Day 0 was designated as the day of the first vincristine treatment. The number of mitotic TVT cells was 14.0±3.6 per 100 cells on Day 2, and decreased gradually during the course of the treatments, and 2.7±1.1per 100 cells on Day 14 was observed. The lymphoid cells was 4.4±2.1 per 100 cells on Day 2, and increased to 76.9±5.9 per 100 cells on Day 14. Some TVT cells that were surrounded by several lymphoid cells were frequently seen on Day 14. Plasma cells and neutrophils increased slowly, but they were few in proportion to other cells. The caudal-axillary skin mass showed complete regression after a total of 4 treatments. The nasal swelling also regressed and no more epistaxis and sneezing were observed on Day 7. After 3 month follow, the patient didn't show any recurrence after the treatments cease. It showed good prognosis. |
本系統中英文摘要資訊取自各篇刊載內容。