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題 名 | Immunohistochemical Study on the Expression of c-erbB-2 Oncoprotein in Gastric Cancer=胃癌c-erbB-2致癌蛋白表現的免疫組織化學研究 |
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作 者 | 李威傑; 洪瑞隆; 孫家棟; 陳炯年; 陳楷模; | 書刊名 | 慈濟醫學 |
卷 期 | 7:3 1995.09[民84.09] |
頁 次 | 頁159-165 |
分類號 | 415.527 |
關鍵詞 | 胃癌; c-erbB-2致癌蛋白; 免疫組織化學法; Gastric cancer; C-erbB-2 oncoprotein; Immunohistochemistry; |
語 文 | 英文(English) |
中文摘要 | 本研究是以免疫組織化學法研究149例原發胃癌的c-erbB致癌基因蛋白 表現。其中38例(2)5腫瘤具有可代表基因擴大表現的陽性染色。在分析各種臨床 病理因素後,c-erbB蛋白表現僅在組織型態具有統計學上的差異[分別為:39.3% 於腸型胃癌,15%於廣泛型,p<0.01]而與年齡,性別,腫瘤部位,肉眼型態,大 小,侵犯深度,淋巴結轉移,遠處轉移,及期別無關。但是在If例轉移的淋巴結 中,有7例具有c- erbB-2蛋白表現陽性染色,包括3例原發腫瘤為陰性染色的病例。 這顯示c-erbB-2蛋白表現與胃癌的轉移可能有關。c-erbB-2蛋白表現陽性及陰性的 病人2年存活率分別為44及56,不具有統計學差異。在分層分析中,c-erbB-2蛋白 表現陽性與腸型或廣泛型胃癌預後無關。這些發現顯示,在胃癌病例中,r-erbB-2 蛋白表現與腫瘤組織型態的不同有關。而c-erbB-2蛋白的存在與否,似乎僅與轉 移潛力有關。(慈濟醫學 1995;7:159-165) |
英文摘要 | Expression of the c-erbB-2 oncogene protein was investigated by immunohistochemistry in 149cases of primary gastric cancer. Positive staining, regarded as an indication of gene amplification, wasevident in 38(25.5) of the tumors. Of various clinicopathological factors considered, a statisticallysignificant difference in association with frequency of expression was noted only for the histologicaltype(39.3 positive staining in intestinal type, 15.4 in diffuse type, p<0.01), but not for age, sex,tumor site, gross type, size, depth of invasion, node metastases, distant metastases and TNM stage.However, in seven often metastatic lymph nodes, the cancer cells stained positive for c-erbB-2, evenwhen the primary tumor stained negative. This finding suggests that c-erbB-2 overexpression may beassociated with the metastatic potential of gastric cancer. The 2-year survival rates of patients withpositive and negative c-erbB-2 protein were 44 and 56, respectively, which is without statisticaldifference. In subgroup analysis, erbB-2 expression was not associated with poorer prognosis in theintestinal type or the diffuse type gastric cancer. These findings indicate that, in the case of humangastric cancer, expression of c-erbB-2 protein is correlated with tumor histological type, and that thepresence or absence of c-erbB-2 protein may serve as an indicator for potential of distantmetastases.fTzu ChiMedJ 1995; 7:159-165) |
本系統中英文摘要資訊取自各篇刊載內容。