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頁籤選單縮合
題名 | Childhood Leukemias--Current Status and Future Perspective=兒童白血病:現況與展望 |
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作者 | Pui,Ching-Hon; | 書刊名 | 中華民國小兒科醫學會雜誌 |
卷期 | 36:5 民84.09-10 |
頁次 | 頁322-327 |
分類號 | 417.5515 |
關鍵詞 | 兒童; 白血病; Acute lymphoblastic leukemia; Acute myeloid leukemia; Chronic myeloid leukemia; |
語文 | 英文(English) |
英文摘要 | Current chemotherapy will cure at least 65% of children with acute lymphoblastic leukemia (ALL). The major challenge in ALL is to develop effective risk-directed therapy. This approach seeks to improve outcome, through more intensive therapy, for children at high risk of relapse, while reducing the side effects and long-term complications of treatment for those with a high likelihood of cure. The prognosis remains poor for most children with acute myeloid leukemia (AML). Despite the use of intensive chemotherapy and bone marrow transplantation, only 30% to 40% of these patients are long-term survivors. However, research has identified subgroups of patients who will respond well to therapy that is targeted to their specific biologic subtype of AML. Allogeneic bone marrow transplantation remains the only curative treatment for patients with chronic myeloid leukemia. Current efforts focus on improving risk-directed and subtype-specific treatment for the childhood leukemias. Ultimately, it may be possible to target treatments to the specific genetic lesions of leukemic cells. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。