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題 名 | Opioid Receptors and Butorphanol Dependence=類鴉片受體與Butorphanol藥物依賴性 |
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作 者 | 何英剛; | 書刊名 | 藥物食品分析 |
卷 期 | 3:2 1995.07[民84.07] |
頁 次 | 頁87-94 |
分類號 | 418.2132 |
關鍵詞 | 生理依賴性; κ類鴉片受體; Butorphanol; β-funaltrexamine; Naltrindole; Nor-binaltorphimine; Physical dependence; μ-; δ-; κ-opioid receptors; |
語 文 | 英文(English) |
英文摘要 | Butorphanol, a mixed opioid agonist/antagonist, is considered to be a relatively safe drug when used within the therapeutic dose range. However, diversional uses of butorphanoi involving high doses have been documented. In the present review, the relative involvement of u-, δ-, and k- opioid receptors in butorphanol physical dependence in rats is discussed. Physical dependence was produced by continuous intracerebroventricular (icv) infusion of butorphanol (26 nmol/h) for 72 h in male Sprague-Dawley rats. Multiple icv injections of β- funaltrexaimne (β-FNA, a u-antagonist, 12, 24, or 48 nmol/5 ul), naltrindole (NTI, a δ-antagonist, 0.1, 1, or 10 nmol/5 ul), or nor-binaltorphimine (nor-BNI, a k- antagonist, 12, 24, or 48 nmol/9 ul) significantly attenuated the development of butorphanol dependence. Furthermore, icv administration of both NTI (24, 48, or 100 nmol/5 ul) and nor-BNI (3, 10, 20, 48, or 100 nmol/5 ul) precipitated withdrawal behaviors, whereas, β-FNA (12, 24, 48, or 100 nmol/5 ul) was unable to elicit withdrawal signs in butorphanol-dependent rats. The results indicate that the development of butorphanol dependence is due to effects of butorphanol on central u-, δ-, and k-opioid receptors. |
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